Origin of Loading

[WIZARD6787]

Does anyone know the origin of the practice of prescribing loading doses?

For lack of better information I have been using the assumption that it is a hol over from when B12 was first synthesized over 1/2 a century ago.

That the practice originated when B12 deficiency was thought to be a hematological issue exclusively and symptoms were not considered at all in any evaluation other than the recommendations of when to test.

Pretty much loading is rational if the goal is to bring hematological tests into range.

Note: That is scientific as it is repeatable and measurable. It does not always address symptoms.

[clivealive Forum Support]

I remember having loading doses of cyanocobalamin starting back on 19th May 1972 (i.e. 52 years ago coming up next month) but I don't recall that I given more than three injections over a few days before being put on a regime of every four weeks for the rest of my life.

They seem to be working as I'm still "clivealive" at the age of 82 😂

[wedgewood in reply to clivealive]

I suppose that was before Hydroxocobalamin was introduced .? The NHS consequently gave fewer b12 injections to PA patients , because they believed it stayed in the system longer .

[WIZARD6787 in reply to wedgewood]

That's a good point. Another decision with total disregard for symptoms. Good to know whatever the criteria the medical profession is using it is not effective treatment for their patients. Of course it always could just be lack of ability.

[ACritical]

I received EOD injections for at least a month that sorted my migraines to what they are now, occasionally very much reduced in duration and severity. Then the injections went 2 a week for awhile , then 1 a week until I finally got the feeling back in my legs and feet after approximately 6 month . From then on 1 a month and more if necessary. My brainfog cleared to what it is now( very much better) I can retain what I have read. I had a female neurologist who trained in Poland as well as Sweden, before she settled in the U.K. Only to be asked to leave when she was no longer necessary. The same happened to the very knowledgeable GP from Lebanon in my GP practice. I was treated regarding my symptoms not by some higher edict.

[WIZARD6787 in reply to ACritical]

Thank you so much. Very helpful information! If you would care to put in the effort I would like to know when you started treatment.

[ACritical in reply to WIZARD6787]

2002/2003

[WIZARD6787 in reply to ACritical]

Thank you!

[wedgewood in reply to ACritical]

Wow ! You give lots of PA patients courage to persist and hope, by letting us know that ! Thank you !

[Nackapan in reply to ACritical]

One of my major symptons were horrendous migraines and vertigo.I after going through all 6 gps at my surgery and seeing 3 neurologists .

They all thought the severe symptons must have another cause.

Alot thought mental health problems as the tests showed nothing more and simply didn't believe very low b1e can do this !

Ad we all know we don't need to find anything else to be very ill !!

As nothing else found I remained on every other day b12 injections for about 6 months ( after an unwanted 5 week break after loading doses)

Then 2 a week for months then every 5 days ect.

That G.p let me go at my pace .

My aim was monthly .

As at that time it made sense not to need them more .

I did have reactions from b12 injections that knocked me for 6 and triggered more head pain .

However was getting more and more shut down without them.

Soon my aim changed to how ever many injections kept me as well as possible

The prescription at that time said something like ;

Hydroxcobalamin 1mg/1ml injectikn as required .

Others have had this written and posted this sort of prescription on here

I was then on every 2 weeks for ? 2 years.

That's what my prescription still is despite many attempts to reduce it .

I bought some as the pandemic hit and was unsure if I'd get it suddenly changed to tablets.

That caused anxiety.

I'm also not returning to that dark place .

Such a shame you lost those talented doctors .

Brexit had alot to answer for.

Still short of all medical staff.

[SuperhydroIM]

I do up my injections to every day whenever I feel like it. Is this considered loading? The only “study” that works for me is “I feel good” study :))