Has anyone changed from hydroxy to cyano and seen a big difference in symptoms. I.e, sluggishness, itchy skin etc.

[Clara5672]

How often to si cyano

[pvanderaa]

Hydroxo was monthly injections and cyano is weekly injections to keep my symptoms at bay

[clivealive Forum Support]

Hi Clara5672

I'm the other way round. I was "started" on cyano every four weeks way back in 1972 (so that's 49 years ago) but when hydroxo was generally introduced in the mid 1980s I had a very allergic reaction to it and was put back onto cyano which I now have every three weeks.

I guess we are all different and some ingredient or other will affect us more than others.

I am not a medically trained person and I wish you well

[Gambit62 Administrator]

there isn't any clear answer - it varies from person to person. On average people retain hydroxo twice as long as cyano but in the studies that got to this result there was a lot of variation and some retained cyano longer than hydroxo so all you can really do is keep an eye on symptoms and use that to determine the frequency.

[Clara5672 in reply to Gambit62]

Thank you gambit62. I'm at my whitts end to be honest. I si hydroxy eod and the beginning of the week I felt like I could run a marathon. So much energy and good mood. Yesterday I si and I feel I could sleep for a week. Hence the reason I'm wondering if I should try cyano. I'm only 4/5 months into si, but I'm wondering will I ever get my energy levels back up. Other symptoms are easing I'm glad to say

[Gambit62 Administrator in reply to Clara5672]

there are a lot of things that can affect energy levels - you could be having an off day. Some people find that they feel tired for a day or so after an injection. I don't think there is any point in trying a different type of cobalamin if you responded when to the hydroxo originally.You might also want to get thyroid levels checked in case it is something to do with that.

[smegalsmegal]

Hi Clara. I was on the cyanofor about 6 months via my gp. I developed some kind of itchy rash after a while. I decided to switch the methyl B12 when I started to self inject. It took quite a while for the itchy bumps to disappear. Then many months later I took a dose of the cyano because I ran out of the methyl and within a couple of days I had the itchy rash come back and it took again some time for it to go away even though I only had one dose of it.