Georgetown Nilotinib Phase II results now available (article, research paper, editorial)

[jeffreyn]

The other nilotinib Phase II trial (i.e. Georgetown) has released its results.

NPR.ORG article:

"A Cancer Drug For Parkinson's? New Study Raises Hope, Draws Criticism"

npr.org/sections/health-sho...

Research paper (open access):

"Nilotinib Effects on Safety, Tolerability, and Potential Biomarkers in Parkinson Disease A Phase 2 Randomized Clinical Trial"

jamanetwork.com/journals/ja...

Editorial (not open access, but available via ResearchGate if you are a member):

"The Narrowing Path for Nilotinib and Other Potential Disease-Modifying Therapies for Parkinson Disease"

jamanetwork.com/journals/ja...

[zhifu]

good news. awesome.

[park_bear]

Thanks for bringing this to our attention.

Clinical improvement was slight - 2 points on the UPDRS- III motor scale, and this did not surmount the confidence interval, in other words, was not statistically significant. See figure 2 of the supplementary data: cdn.jamanetwork.com/ama/con...