Zishenpingchan: Never heard of the stuff, but worth a look?

[MBAnderson]

July 13, 2018

" ... can markedly improve dyskinesia and delay the progression of Parkinson's disease, with especially dramatic improvements of non-motor symptoms."

ncbi.nlm.nih.gov/pubmed/300...

sciencedirect.com/science/a...

[Prakash1]

Where can we buy this ?

[MBAnderson in reply to Prakash1]

Good question. Someone else just asked me that a couple hours ago, but as I just heard of this stuff today, I know little about it or where to buy it, but it seems pretty intriguing.

[Hidden in reply to MBAnderson]

Thanks for sharing this info.

[junipertree]

Thanks for posting this. I plan to look into this formula with a local Chinese Medicine practitioner. If I have success, I will report back.

Examine.com sites a study that ranks Zishenpingchan’a first ingredient—Radix Rehmanniae—as one of the top Chinese Medicine herbs in treating diseases of cognitive decline. The study also sites licorice root (Glycyrrhiza glabra).

I’ve been making tea with licorice root, which according to a study “may help to inhibit dopaminergic neuronal cell death and could help slow the progression of Parkinson’s disease.” Plus, it tastes good!

ncbi.nlm.nih.gov/pubmed/218...

neurosciencenews.com/licori...

examine.com/supplements/lic...

[MBAnderson in reply to junipertree]

It's getting more interesting

[Juliegrace]

I asked a Chinese friend to look into it and tomorrow I'll contact an acupuncturist I know who also works with Chinese herbs/medicine.

[junipertree in reply to Juliegrace]

In case this helps with your research, it looks like there is already a thread on this :

healthunlocked.com/parkinso...

The linked abstract in this thread has this list of ingredients:

Radix Rehmanniae preparata, Lycium barbarum, Herba Taxilli, Rhizoma Gastrodiae, Stiff Silkorm, Curcuma phaeocaulis, Radix Paeoniae Alba, Rhizoma Arisaematis, Scorpio and Centipede. (I sent this list to a CA Chinese Medicine practitioner, who said "interesting formula" but she believes scorpio and centipede are banned from import.)

iqbaliqbal found the formulation used and has contacted the company to find out about availability: Shudihuang 15 g, Gouqi 15 g, Sangjisheng 20 g, Tianma 15 g, Jiangcan 10 g, Ezhu 15 g, Baishaoyao 20 g, Tiannanxing 15 g, Quanxie 3 g, and Wugong 3 g. . . by Jiangyin Tianjiang Pharmaceutical Co., Ltd.

[JANVAN in reply to junipertree]

Yes, I would say .......go for it !!! Here in Europe, I will also (had already one) ask

all acupuncturists and Chinese if they know something about it, and if they can help me.............!!

[Juliegrace in reply to junipertree]

My friend found another study with a slightly different formula, omitting the scorpion and centipede.

[reedboat2 in reply to Juliegrace]

I'd like to hear about how that goes

[Juliegrace in reply to reedboat2]

I think Littlesky has the inside track, although my friend is going to keep looking.

[Littlesky]

I work in China and asked one of my colleagues in Beijing to check it out. She reached one of the clinic directors (Dr. Yuan) mentioned in the study in Shanghai where the trials are taking place. He told her that the current trial (Shanghai patients only) will be completed at end September and that there will be another trial (China-wide) before the compound becomes generally available. He offered to meet with me in October when I'm in China so will try to learn more then. Meanwhile, it will be interesting to hear if Iqbaliqbal learns otherwise from the manufacturer!

[Farooqji in reply to Littlesky]

Had you met the doctor. Request updates

[Littlesky in reply to Farooqji]

Sorry iqbaliqbal - I'd replied privately to others who inquired but should have done publicly. In the end, I did not meet Dr. Yuan because a doctor friend in Beijing did some research for me and learned the formula does nothing to aid motor symptoms. I have tremor-dominant PD and 10 years from dx, tremor is still my only symptom. Here's what he said....

Attached is the research paper written by Drs from Shanghai you mentioned, it is about their study in Parkinson disease and you can read the English abstract. The results showed that Zishen pingchan granules cannot treat motor symptom but can improve some other symptoms, like sweat, constipation and sleeping, the granules are a mixture of 10 herbals which we can prescribe here in Beijing and you boil and drink.

Best.

Roger

<滋肾平颤颗粒治疗帕金森病非运动症状临床研究_袁晓蕾.pdf>

[Farooqji in reply to Littlesky]

Thanks a lot.

[reedboat2]

I ordered some of this formula last week from an acupuncturist. He took my pulses, modified it a little bit, and sent the Rx to an herbal clinic in my area. I haven't received it yet, but when I do I'll post the results. I asked the TCM doctor about the centipedes and scorpions. He said all "Liver-Wind" formulas have those. WTH I guess I'll try it.

[Juliegrace in reply to reedboat2]

Where are you located? Please report back once you receive it. I'm very curious as to the form it will come in. My friend said that a TCM doctor would base the formula on a diagnosis (which it sounds like yours did). Have you been seeing your acupuncturist for long? I tried it early on but did not respond.

[reedboat2 in reply to Juliegrace]

I live in SF Bay Area, Marin County. The TCM herbal clinic I mentioned is Pine St Clinic, San Anselmo, CA

[Juliegrace in reply to reedboat2]

I'm two hours from Seattle, but it might be worth the trip. I'll wait on your feedback, thanks.

[reedboat2 in reply to Juliegrace]

My acupuncturist said it’s a pretty common Liver-Wind formula and all the herbs were available. You could have a TCM Dr call in a prescription to Pine St, or there’s probably a good TCM herb source in Seattle. Bastyr could probably steer you there. Anyhow good luck and I’ll let you know what I find out.

[MBAnderson in reply to reedboat2]

Have you been taking it for a couple months now and if so how do you feel about it?

[Tucum]

I bought it.

[MBAnderson in reply to Tucum]

Did you get it from the same pharmacy in San Anselmo?

[Farooqji in reply to MBAnderson]

I had found a Chinese company which also can make it on order in small quantities (no minimum quantity required ) but it's expensive. I am copying and pasting the email from that company dated 21 September 2018

"

Blue Light Inc. sent you a new message

A

Ann Wang

to me

Aug 21Details

Hi there! You've got a new message

from Blue Light Inc.

Hi Iqbaliqbal, Our company do not have this formula, but my herbal pharmacy is able to help you to make this formula. the ingredients of the Zishenpingchan Formulas

are:

Dihuang (Radix Rehmanniae) 15 g,

Gouqizi (Fructus Lycii) 15 g,

Sang ji sheng (Taxillus sutchuenensis Danser) 20 g,

Tianma (Rhizoma Gastrodiae) 15 g,

Jiang can (Bombyx Batryticatus) 10 g,

Ezhu (Rhizoma Curcumae Phaeocaulis) 15 g,

Bai shao (Radix Paeoniae Alba) 20 g,

Tian nan xing (Rhizoma Arisaematis Erubescentis) 15 g,

Quan xie (Scorpio) 3 g,

Wugong (Scolopendra) 3 g.

The formulas are special made for each person with 5 time concentrated granule extracts. It is 100g per bottle, you need to take 5 g, 2 time a day, please mix the formula in hot water, drink as a herbal tea. You need to take for 3 months to see the full benefit. The formula is $25 per bottle, 3 months you would need 9 bottles, plus shipment.

Since the formula is especially made for you, prepayment is needed.

Please let me know if you are interested. please call 607-275-9697 to place your order.

Best regards,

Dr. Ann Wang"

[MBAnderson in reply to Farooqji]

Looks like reedboat2 and Tucum bought some from a pharmacy in San Anselmo, probably bought a smaller quantity and without shipping, so we should see what they paid and how much they got. It also looked like he needed a prescription from an acupuncturist. I don't see a traditional doctor writing a prescription for this.

[MissRita in reply to Farooqji]

I just ordered this. This doctor happens to be about 45 minutes away from me. Do you know if it helps with tremors?

[betil1 in reply to Farooqji]

google.com/url?sa=t&source=...

[Farooqji in reply to Tucum]

from where? and what was the minimum amount and cost

[MissRita in reply to Farooqji]

It’s $25 a bottle and each bottle lasts 10 days if you take six scoops a day. Three scoops in the morning on an empty stomach and three scoops at night and empty stomach.

[MissRita in reply to Farooqji]

The doctor that I am talking about and then related to in this post is located in Ithaca New York.

[Farooqji]

reedboat2 and Tucum are requested to provide their feedback of source of purchase. reedboat2 can also share whether he/she has felt some improvement , since he/she had purchased it since quite a while

[NewHope1961]

Everything I have read reports no know side effects?

[MBAnderson in reply to NewHope1961]

I don't doubt that the stuff works for some people and that it's mostly safe.

I've been looking up the ingredients and listing them in a website that determines contraindication issues, but stopped because none are known (to us.)

I'm hoping some PWP try it and report back on its effectiveness.

[MissRita in reply to NewHope1961]

From the doctors office that I spoke to they said there are no side effects.

[junipertree]

Sorry such a time gap. Travel and life events intervened. This is what I heard back from two California Chinese Medicine Doctors when I inquired Zishenpingchan. know it’s not always possible, but they both strongly suggested that it was best to prescribe formulas in accordance with an individual’s constitution as assessed in person. One thought that scorpio and centipede might be too strong for some PD patients.

The other wrote this:

Is there information regarding dosage frequency of administration and what stage and or symptoms of PD were the criteria for eligibility in the Chinese study? Simply replicating the formula as an adjunct to treatment with l-Dopa and or other therapies or medications may not confer the benefits that you might expect. Also, it’s important to know who was excluded from the study and who dropped out and for what reasons.

But if you want to experiment on you—hopefully with the aid of some professional with experience in Chinese herbal medicine and neurological disorders—here is an herbal dispensary that will put the ingredients together and ship them to you.

Spring Wind Dispensary

springwinddispensary.com/in...

Hope people experience positive, healing responses and report back. Thanks.

[MBAnderson in reply to junipertree]

Thank you, Junipertree.

I have been concerned that some Chinese herbs are potent enough for contraindication concerns.

I'd sure like to know what they extract from a centipede and scorpion.

Do you suppose they put a handful in a meat grinder and crank away?

I can imagine a ground-up centipede will take care of constipation pretty well.

I know a lot of Chinese herbs been in use for thousands of years, but I don't understand how they discovered the stuff if not for trial and error? I mean, how many people were poisoned for them to come up with this combination of ingredients?

At some point in the process somebody had to be given centipede juice for the 1st time. Who thought that might be a good idea?

[HekateMoon in reply to MBAnderson]

🤣🤣🤣🤣 oh Mark, that post on centipede as constipation remedy is soo funny. Made my day!

[junipertree]

I appreciate your centipede musings: sense of humor being one of the most powerful medicines!

Interesting that science seems more and more to validate the underpinnings and efficacy these ancient systems (including use of herbs). Heartening how much alternative experimentation is underway.

[HekateMoon]

This is an interesting post. I supose a TCM practicioner could prescribe it?

[MrDavid]

I have come across zifengzhizhan, is this the same stuff.....