Traditional Chinese medicine (ZAZ2) is a granule made up of 14 kinds of herbs: Uncaria rhynchophylla 10 g, Rehmanniae radix 10 g, Cornus officinalis 8 g, Asnaragus cochinchinensic 10 g, Paeonia lactiflora 10 g, Desertliving cistanche 10 g, Puerariae radix 10 g, Arisaema consanguineum Schott 10 g, Salviae Miltiorrhizae radix 10 g, Acorus tatarinowii 10 g, Curcuma longa Linn 12 g, Morindae officinalis radix 10 g, Rhizoma gastrodiae 10 g, and Rhizoma chuanxiong 10 g.
In a trial, Patients took either ZAZ2 () or placebo granule () in a blind manner for 13 weeks while maintaining other anti-Parkinson medications unchanged. All participants wore a motion logger, and we analyzed the power-law temporal autocorrelation of the motion logger records taken on 3 occasions (before, one week, and 13 weeks after the drug administration). Drug efficacy was evaluated with the conventional Unified Parkinson Disease Rating Scale (UPDRS), as well as the power-law exponent α, which corresponds to the level of physical activity of the patients. ZAZ2 but not placebo granule improved the awake-sleep rhythm, the UPDRS Part II, Part II + III, and Part IV scores, and the α values. The results indicate that ZAZ2 improved activities of daily living (ADL) of parkinsonism and, thus, is a potentially suitable drug for long-term use.
A Cure for Parkinson's Disease
Parkinson's Disease A Strange Gift
