PPIs and Ibs

[Spaceboy]

Taken every PPI now, they all seem to make my IBS much worse. Is this normal?

[Paulbrighton]

They all give me diarrhoea every morning (I take them at night) I’ve heard a lot of people have this. I have only tried lanzoprazole and esomeprazole though.

[Spaceboy in reply to Paulbrighton]

Are they effective for you when taken at night? How long before bed do you take them?

[Paulbrighton in reply to Spaceboy]

I take at bed time. Seem to work. I was in 30mg lanzoprazole but I’m trying to reduce the dose so I just take one esomeprazole tab for now. I have a bit of acid with it but not too much.

[Paulbrighton in reply to Paulbrighton]

20mg

[Spaceboy in reply to Paulbrighton]

How long should I give a PPI before giving up? Been on nexium 20mg, and now 30mg two days of each and no improvement, worse if anything

[Paulbrighton in reply to Spaceboy]

Why not up the dose to 40mg and see how I feel. I often take 40mg osemaprazole (Nexium)