Methotrexate and sulfadiazine

[Dawnee28]

Hi everyone, just prescribed sulfadiazine alongside methotrexate injections as the MTX doesn't seem to be helping. Anyone have any experiences taking these 2 meds together, bit apprehensive about starting the sulfadiazine after reading side effects.....although to be fair all side effects rubbish .. Thanks for any replies Dawn

[helixhelix]

I take both, and hydroxychloroquine as well. All fine, and few/no side effects now (apart from the bright orange wee). Sulpha was horrible to start with, as it gave me an extremely excitable digestive system. To the extent that I couldn't eat or drink anything outside the house for fear of the results, very embarrassing. However it only lasted a couple of months and then calmed down and has been fine since.

[Dawnee28 in reply to helixhelix]

Oh dear I have IBS so I guess I'm going to have to stay close to home for a while or stock up on Imodium lol

[Newjobnewlife]

I started sulphazalazine with methotrexate orally as part of the COBRA regime some 4 months ago.(though about to change to MXT by injection.)

Yes it did cause some bowel disturbance at first but this settled.It does take time to kick in and I am now on 1.5 mg twice daily

My pain, stiffness and swelling are now so much more under control-in fact I spoke to my nurse yesterday regarding reducing the doses-a bit to soon as yet!!

I hope it works as well for you-good luck-I also worried about the side effects of all the medication I take-but so far-bloods all fine!

I must say though-that through the dark days and fog of this crazy disease I couldn't have got to where I am now without the support of the AMAZING Bristol multidisciplinary team-I hope that you have similar support🌻

[Newjobnewlife in reply to Newjobnewlife]

Whoops -meant 1.5 g!!!!

[stbernhard]

I have been on Sulfasalazine (3 grams a day, now gradually reducing) and MTX for six years and on CIMZIA for the last four years. I have never paid any attention to side effects as long as they no worse than the pain they relieved me off. I am lucky to have these wonderful drugs. I hope they work for you as well as they did for me. All the very best.