I've been on Mtx for 3 months now at 15mg which is increasing to 20 mg this week after seeing rheumy nurse last week also increasing Folic Acid to 5mg 6 days a week. My bloods are now showing normal and the swelling has gone down but still in pain. I hate colds and I have just got another one that is 3 in the same number of months, all nasty and long lasting. I know the drug suppresses the immune system and this is why I keep getting them but it is really getting me down. I am wondering if the increase in Folic Acid helps my immune system. I have been taking probiotics to help with the slight GI problems but not sure if it does any good. I feel that I don't want to mix with people in case they are carrying any infections. Any advice would be greatly appreciated.