How many others have experience Meds stopping working? All has been good for 6 months and now I feel back to square one!

[MrsSMC]

[Hidden]

So sorry to learn this - which meds have you tried and when do you next see your rheumatologist? Tilda

[MrsSMC]

Hi Tilda

I first tried mex, but liver didn't agree I am now on Hurima and leflunomide and just been given a steroid injection to try and kick start the meds. As you can imagine I am totally fed up and in pain! Back to docs in 10 weeks.

Sarah

[cathie]

So sorry to hear this. Mtx damaged my liver so it was withdrawn. I've found that it's easier for anti tnf to work without mtx than I'd thought. I hope things resolve themselves for you soon

[RichardG in reply to cathie]

Interested that anti tnf works for you without mtx. When I stopped mtx for 2 weeks due to severe viral infection (still took humeria) my wrists started hurting again.

[cathie in reply to RichardG]

I didn't mean to say it did Richard. I'm in a horrible mix up, off everything excep cocodamol and with flares in hands and pain in knee. Bit of a crisis actually!

[RichardG in reply to cathie]

Hope you find something that works soon. I know how demoralising it is to be back to square one after being pain free for a while.

[cathie in reply to RichardG]

Thanks!

[RichardG]

Depends what you are taking. I was on mtx and plaqunil for around 2 years and this worked reasonably well. However the RA got steadily worse and started to have trouble focusing so stopped plaqunil and eyesight returned to normal. Introduction of humeria and mtx was a significant improvement for me and been on this for nearly 2 years and RA is negligible. There are plenty of alternatives if one treatment stops working. You need to talk to your rhumy team.

[Shell1967]

Hi this question has hit a nerve with me too :((( I have been on methotrexate for 16 months,95%pain free all this time !! It was wonderful my miracle drug,but from Christmas I feel its losing its effectiveness ::((( my fingers are now stiff and sore again and my wrists are started to feel tender and this morning my balls of feet(my first point of pain) are hurting ,its all come flooding back how painful my balls of feet were and now are again, I'm seeing the rheumy on the 13 th so will talk to him about it.i started on 15 mg mtx then it was increased to 17.5 mg but I'm wondering does it lose its effect after a while.such a huge shame after a relatively pain free time for many months:(((I feel like you I'm heading straight back to square one again.take care michelle x