Anyone know about or try LDD (low dose ... - My Fibro Community

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Anyone know about or try LDD (low dose dipyridamole) for fibro pain relief?

Julie8787
Julie8787

Hi All,

I recently read an article that I found interesting about a new medicine called Low Dose Dipyridamole which helps fibromyalgia patients with pain relief.

Is anyone familiar with it or has anyone here ever tried it?

Here is a link to the article if any of you would like to read it:

medium.com/@hablerannie/dip...

The information below was copied and pasted from the patent which was filed on LDD:

Treatment of chronic rheumatic or fibromyalgia pain

In order to determine the effect of low dose oral dipyridamole for treating chronic rheumatic or fibromyalgia pain, 3 subjects with chronic rheumatic pain were treated with the addition of low dose oral dipyridamole prepared according to Example 1 to their present pain regimen. Subject 1 (39 y/o female) was treated with 2 mg taken once daily with the first daily dose of oxycodone. Subject 2 (40 y/o male) was treated with 2mg or 5mg taken once daily, in conjunction with oxycodone. Subject 3 (45 y/o female) was treated with 2mg, 5mg or lOmg taken once daily with PERCOCET.

Subject 1 : After adding dipyridamole 2 mg the subject had complete relief of pain related to chronic fibromyalgia. She had previously been dependent on oxycodone 10 mg twice daily with incomplete pain relief.

Subject 2: After adding dipyridamole 2 mg the subject had complete relief of pain related to chronic rheumatic pain in the joints. When trying lOmg instead, there was negligible pain relief. 2mg was continued for 12 months. Within 3 months of use, this subject was able to completely wean off oxycodone while maintaining pain relief.

Subject 3: After adding dipyridamole 2 mg the subject had complete relief of pain related to chronic fibromyalgia and rheumatoid arthritis. At a 5mg dose, she experienced less pain relief, so she resumed 2mg. She had previously been dependent on Percocet with incomplete pain relief. Percocet was slowly weaned off after 2 months of low dose dipyridamole use.

This example illustrates that low dose oral dipyridamole is effective for the treatment of chronic rheumatic and fibromyalgia pain. It also suggests that low dose oral dipyridamole can serve as a substitute for opiates in some patients.

6 Replies
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Thanks for sharing information .

Hi Julie, interesting. I read that LDD blocks opiates? So I wonder if you are taking tramadol/Oramorph then would it cause withdrawal symptoms? If you stopped taking your current medication because there would be no point taking it. Hope someone replies who has tried it and their experience. I will certainly ask at the pain clinic.

I think you may be confusing it with LDN (low dose naltrexone). LDN is an opiate antagonist and shouldn't be taken at the same as opiate drugs. However, LDD (low dose dipyridamole) is a different kind of medication. Hope this clarifies things.

Thanks Julie for clarifying. All these acronyms, does get me in a twist, mind you it doesn’t take much, I blame the drugs (LOL).

Let us know if you end up deciding to start with either LDD or LDN!

Yes. I’ve been on LDN for 2 years and I’m so happy that it has helped my fibromyalgia pain