« Should you be fortunate enough to enjoy a long life, there is a chance you will develop clonal hematopoiesis (CH), even if you never know about it. Over the course of our lives, long-lived cells within self-renewing tissues such as hematopoietic stem cells (HSCs) can acquire and accumulate somatic mutations. If these mutations confer a fitness advantage, these mutated HSCs will have an increased output compared with nonmutant cells, leading to CH. With each decade of age older than 40, the prevalence of CH increases so that, by age 70, 10% to 20% of individuals will have detectable CH. A restricted set of genes has been reported to be mutated in CH which is also mutated in myeloid malignancies, hinting that there is a continuum in transformation »
Patience is a virtue: « Should you be fortunate... - MPN Voice
Patience is a virtue
Written by
Manouche
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2 Replies
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Oh well, I'll still go for the long life option!
Like my family motto "PATIENTIA VINCIT"! 👍
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