What do we know about future treatments of AML ? Is there anything hopeful in the horizon?

[Aneliv9]

Is there any hope for cure or breakthrough treatments?

[Manouche]

« “One of my patients on the trial was so critically ill when she was initially diagnosed that she was told to get her affairs in order, but her AML was put into remission, and she has been receiving oral azacitidine maintenance therapy as part of the QUAZAR trial since 2013,” Dr. Roboz said.

« This is the first time a maintenance treatment for AML has shown such a strong benefit for patients, and it is already being adopted as part of standard care. »

projecttopics.org/new-maint...

[Aneliv9 in reply to Manouche]

🙏 so you believe there's hope? Isn't AML more aggressive after myelofibrosis rather than aml de novo?

[Manouche in reply to Aneliv9]

Of course there’s hope! I never heard that aml was more aggressive after MF. The diverse acquired mutations dictate the aggressiveness of AML

[cmc_ufl in reply to Manouche]

I have also never heard that AML was more aggressive after MF, although it could make sense that the scarring in the bone marrow could contribute to a more aggressive disease. I believe the most commonly cited risk factors in AML is the specific mutation profile of the patient.

[Manouche in reply to Aneliv9]

During the Acute Leukemia Forum 2021, the AML Hub spoke to Jerry L. Spivak, Johns Hopkins University, Baltimore, US. We asked, How can advances in polycythemia vera research help us to better understand AML?aml-hub.com/medical-informa...