Mpn treatment?

[Aojai]

pvreporter.com/immunotherap...

Can group members pl read and elaborate i read a bit it ws shared on multiple pages for mpns

[Aojai]

Whats in regard to immunotherapy ??

[Manouche]

« Conclusions

During the last years, an impressive progress has been made in understanding the molecular mechanisms driving MPN development and leukemic transformation. Moreover, the role of pro- inflammatory cytokines and immunosuppressive myeloid cells in the bone marrow of MPN patients in mediating leukemia immune escape was elucidated in detail. Multiple studies are ongoing to evaluate novel treatment strategies aiming to overcome the immunosuppressive mechanisms and to enhance an anti-leukemia immune response. Although allo-HSCT is still the only potentially curative treatment for most patients suffering from myeloid malignancies, there are promising novel strategies effectively incorporating immunotherapeutic strategies to overcome the unmet need for an effective treatment for patients with hematologic malignancies. However, myeloid tumors were found to exhibit a variety of strategies to successfully undergo immune evasion making effective immunotherapy difficult. Nevertheless, target-specific cytotoxic T-cell transfer, hypomethylating agents, ICB, specific antibodies and tumor vaccination are promising novel immunotherapeutic approaches against myeloid disorders. The successful treatment will always depend on the detailed understanding of the underlying disease, its microenvironment, genetic aberrations, and potential immune escape mechanisms to successfully treat patients either as monotherapy or in a combination approach »