Jak2 burden

[Zar77]

Hi

What is jak2+ mutant burden 56% mean I have no clue.

[mhos61]

Hi,

I asked this question awhile back. Maz the forum administrator asked Professor Harrison for a definitive answer. Briefly, it is what proportion of the Jak2 is abnormal, in your case that would be 56%.

[hunter5582]

The Janus Kinas 2 signaling system is responsible for driving hematopoiesis (make blood cells). Also drives production (overproduction) of inflammatory cytokines. The Janus Kinase 2 gene is composed of a set of alleles. When some of these alleles are mutated, you show as JAK2+. The percentage of the alleles that are mutated = your allele burden. The mutant allele burden is predictive of the course of your PV. Less than 50% is typically predictive of a more favorable/benign course of the PV. Greater than 50% is predictive of being more symptomatic. You are close to that line. I think it is very important for you to talk to a knowledgeable provider about how to interpret this finding. Get the doc to explain what this means specifically for you. Many GPs and even hematologists treat so few MPN patients that they just do not have the KSAs that you really need. You may want to seek a consultation with a true MPN-expert doc even if you have to travel to do so. I found a great MPN expert on this list of patient-recommended docs mpnforum.com/list-hem/ . Hope you find the information you need. You have a fundamental right to have your provider fully explain this sort of result to you. Please advocate for yourself and assert your right to be fully informed.

[Zar77 in reply to hunter5582]

Thank you for explaining. My consultant doesn’t explain stuff he’s waiting for my bone marrow results and then hopefully will explain what’s happening. I see him in 5 weeks.

[Skye333 in reply to hunter5582]

Hi I have MF and I am currently trialing Tamoxifen. I am over halfway through the trial which is 6 months. At 3 months in I had all my blood test to see how I Was responding. Unfortunately my Allele burden had only reduced by a very small amount. They are looking for a 50% reduction at that stage so to say I was disappointed was an understatement. I am now on double dose for the second 3 months to see if that works for me. My 6months is up in 5 weeks time and then I will have all the blood tests again and the dreaded Bone Marrow Biopsy. It will take a few weeks until the results are back.

[Zar77 in reply to Skye333]

Best of luck with your treatment. I hope you get the results you are looking for.