I found this article about "chemo rage" that I thought would be helpful. Here is the link:

[mammared]

ncbi.nlm.nih.gov/pmc/articl...

[AMD6yr]

Thanks for your reply.Have you READ that article? it was huge! and the only reference I could find was to "receptor for advance glycation end product (RAGE)", describing the neuron(?) involved. It talked of fatigue and other mental conditions such as schizophrenia and behavior changes but didn't actually refer to anger. Did I miss that? It DOES make me aware of two things; one - someone IS studying the impact on mental states, not just physical impacts of treatment options, and two, that I am LUCKY I don't have most - if not all - those issues! I should be grateful for the health I DO have and enjoy each day I have!! It's humbling, and I am sorry for the pain and suffering so many others have. I'm gonna go hug my horse - OH - and my husband!! Thanks for writing!

[mammared in reply to AMD6yr]

Yes, I read it and maybe should have warned about the length. Also, that the chemo induced moods are toward the latter part of the article. I am happy that you gleaned something from all that reading. I wish you well.

[Rachelthepotter]

V interesting article :thank you for posting the link. What I got from it was the concept of behavioral toxicity , which included fatigue, rage, fuzzy thinking, depression and inertia, and that those states all had a link to the changes caused by both cancers, and by the cytotoxic drugs used to,

treat them. So, if someone hints those things are all in my head, or if I’m secretly concerned that maybe I am going nuts, I can say - yes, and its the unbalanced cytokines and inflamatory metabolic products of the MF and the hydrea/ rux that put them there.

I had a horrible reaction to the hydrea I was first treated with, and posted about it here. Acute behavioral toxicity, as the article would say.

Rux is better, but I still get bursts of anger, and think in circles at times. And get tired.

I fond downloading the pdf made it much easier to read and understand the gist of the article.

All the best, and keep posting.

Rachel

[mammared in reply to Rachelthepotter]

Wishing you the best and hoping that those cytokines of yours calm down soon. I am sorry that you have had such a rough time of it.

[Rachelthepotter in reply to mammared]

Feeling better now: it did help to realise that the outbursts weren’t just me, and that physical changes can and do trigger mental states. It may also have helped my family and friends to know that.

Do keep posting.

Rachel

[Wyebird]

Thank you very much. I have scanned this. I’m going to print and read at leisure.

I would never have researched into this so much appreciated.

It is so applicable to how I feel.

I just thought it was me. Now I know it’s real and my thoughts and concentration are greatly impaired.

[katiewalsh]

Hi. Does it discuss the dosage? My understanding is our doses are far less than the chemo most think of which is IV and usually causes total loss of hair. Thanks for letting me know if those who’ve read it know. Katie

[mammared]

The article discusses the side effects of chemo and how each body system reacts causing the side effect to happen . Everyone's body is different of course. It does give information regarding what is called dosage associated molecular patterns or DAMPS. Even at low doses some individuals fail treatment because of side effects while others go on to enjoy the benefit for their particular cancer.

There are many oral chemo drugs for all types of cancer as well as those that require IV infusion. Ongoing research in the realm of MPN's using Next Generation Sequencing (NGS) and other newer methods to determine a patient's diagnosis have significantly improved the prognosis for many patients. I do hope that this is of some help to you.