This may be of interest to some - it is alleged that there may now be people presenting with coeliac disease without HLA DQ2 and/or DQ8 ..

[Lynxcat]

I am not sure whether there are any other articles or facts that can confirm this article. If I can find more information - or indeed if any of you have further knowledge of this fact then please add what you may know in the comments below.

Here is the extract:

More than 90% of people proven to have celiac disease carry one or both of two white blood cell protein patterns or human leukocyte antigen (HLA) patterns HLA DQ2 and/or DQ8. However, so do 35-45% of the general U.S. population, especially those of Northern European ancestry. Yet celiac disease is present in only 1% of the same population. DQ2 or DQ8 are considered by some experts to be necessary though not sufficient to develop celiac disease. However, celiac disease without those two genes has been reported.

The above is an extract from the following article:

celiac.com/articles/1101/1/...

Dr. Scot Michael Lewey, D.O., FACG, FASGE, FACP, FACOI, FAAP, FACOP, CPE

Board Certified Gastroenterologist (Digestive Diseases Specialist)

Clinical Associate Professor of Medicine

Specializing in Food Allergies and Intolerance, Celiac and Gluten Sensitivity, Colitis and Leaky Gut

Also has a blog with further information that may be of interest to some who are interested in any of the above, which he specializes in:

thefooddoc.com/

[Lynxcat]

According to the following site - 1% of coeliacs do not have either of the genetic markers:

"Ninety-nine percent of celiacs have either HLA-DQ2 or HLA-DQ8,” says Alessio Fasano, MD, medical director at the University of Maryland Center for Celiac Research."

The above is a quote taken from the site below:

livingwithout.com/issues/4_...

[Lynxcat]

According to Wikipedia - 5% of all coeliacs do not have the genetic markers:

Under the following title - Pathophysiology

"Almost all people with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele.[2] However, about 20–30% of people without coeliac disease have also inherited either of these alleles.[21] This suggests additional factors are needed for coeliac disease to develop – that is, the predisposing HLA risk allele is necessary but not sufficient to develop coeliac disease. Furthermore, around 5% of those people who do develop coeliac disease do not have typical HLA-DQ2 or HLA-DQ8 alleles..."

en.wikipedia.org/wiki/Coeli...

[Ruth462]

I'm not surprised at all. I dont have coeliac disease as such but have the syptoms so badly that I have been told to stay by doctors to maintaiin a gluten free diet (non-prescription of course) I suggest that these scientists also look at the changes in the genetic make up of wheat and other cereal crops and note the huge changes (almost 80%) difference than wheat 30 years ago and then acknowledge that GM may be having negative impacts on the human body.

[Jacks]

Celiac disease is not a clear cut genome HLA DQ2/DQ8. It is a multifactorial disorder in which the combination of several genetic factors together with an environmental trigger is necessary for development of the disease. Genetic predisposition to CD is complex and includes the HLA-DQA1*05/ DQB1*02 and HLA-DQA*0301/ DQB*0302 genes as MAJOR FACTORS; these are estimated to explain some 40% of the heritability of the disease. The full article is:

HLA and Non-HLA Genes in Celiac Disease

Zhernakova A, Wijmenga C

Fasano A, Troncone R, Branski D (eds): Frontiers in Celiac Disease. Pediatr Adolesc Med. Basel, Karger, 2008, vol 12, pp 32-45 (DOI: 10.1159/000128613)

It is also the case for Tropical Sprue.

Those of us who have had recent genetic testing for CD know it is part of the ongoing clinical study into genes involved.

[Lynxcat]

I have seen on quite a few sites the following group of letters being used for people who cannot tolerate gluten but at the same time no-one has been able to confirm that they may have coeliac disease. Firstly NCGS, apparently this stands for Non Coeliac Gluten Sensitivity and GRD which stands for Gluten Related Disease.