Metformin again

[Maxone73]

cohort study

nature.com/articles/s41391-...

[j-o-h-n]

Yep we've MET this in many posts before...

Good Luck, Good Health and Good Humor.

j-o-h-n

[Kuanyinismybodhi927]

You might want to look into the addition of Pitavastatin which is a kind of left hook right uppercut combo (The Anti-Cancer Effect of Pitavastatin May Be a Drug-Specific Effect: Subgroup Analysis of the TOHO-LIP Study)

[cujoe in reply to Kuanyinismybodhi927]

Potential statin anti-cancer benefits are not at all limited to Pitavastitin:

(1) Unraveling the Anticancer Potential of Statins: Mechanisms and Clinical Significance, Cancers 2023, 15, 4787.

mdpi.com/2072-6694/15/19/4787

(2) DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nature Cell Biology, 18(11), 1233–1243, 2016.

sci-hub.st/10.1038/ncb3427

(3) Prostate Cancer and the Mevalonate Pathway, International Journal of Molecular Science, 2024.

mdpi.com/1422-0067/25/4/2152

And, as a class, they also present some risks, esp. for PCa patients on ADT.

(4) Effects of statins on mitochondrial pathways, Journal of Cachexia, Sarcopenia and Muscle, 2021; 12: 237–251, Published online 29 January 2021.

ncbi.nlm.nih.gov/pmc/articl...

Stay S & W, Ciao - cujoe