PC drugs and Kidney Disease

[USAFproudmom]

My husband has kidney disease and I am wondering if any of you out that may also have kidney disease may know of any drugs we need to avoid regarding ADT? And/Or procedures? Thank you!

[pjoshea13]

Unfortunately, ADT itself can be a cause of kidney injury, so someone with existing kidney issues should discuss the risk with his doctor.

From a recent paper [1]:

"Although ADT has been shown to improve oncological outcomes against PCa, it can also induce various adverse events, such as ..... acute kidney injury (AKI).

"ADT reduces testosterone levels; consequently, ADT may antagonize the vasodilatory effects of testosterone on renal blood vessels, which could negatively affect renal tubular function. However, the renal impairment due to ADT is transient; i.e., it improves after the discontinuation of ADT. The recovery of serum testosterone levels may contribute to the amelioration of renal impairment induced by ADT. Serum testosterone levels are probably implicated in these changes, but the mechanism has not been studied in detail. With regard to the preservation of renal function and the anti-cancer effect of PCa, intermittent ADT may be a useful treatment for PCa."

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/365...

[USAFproudmom in reply to pjoshea13]

thank you, we are seeing the Nephrologist today and will ask him as well. We will be making a decision on whether to have surgery or radiation therapy. He has some other issues that could make surgery risky.