Blood Protein May Help Predict Diabetes, Death From Cancer— Prostasin commonly found in epithelial cells of organs - MedPage Today, 08/04/22

[cujoe]

MedPage Today article about a blood marker I've never heard of, but one that might be worth getting done. Then again, as it seems to predict lifespan, maybe like the Horvath Clock (see link below), a case where for peace of mind it is better to live in the constant state where, at least for some things, "ignorance is bliss". (sarc)

Most important, in terms of the metabolic activity it seems to be tracking, Prostasin provides further evidence of the need to avoid Insulin Resistance (A major proshea13 target for avoiding/controlling PCa - not to mention T2 diabetes) That it is found in the epithelial cells where most PCa originates (see linked paper), might also give it more relevance for its predictive value for PCa patients.

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From the MedPage article:

"This is the most comprehensive analysis of its kind to date and sheds new light on the biological connection between diabetes and cancer," Gunnar explained in a statement. "Prostasin may be just an indicator that disease might occur, or could be causally relevant, which is exciting because it raises the possibility of targeting this protein with future treatments for both diabetes and cancer."

This protein acts as an epithelial sodium channel stimulator and is already regarded as a tumor biomarker.

"Several diabetes-associated biological pathways, such as inflammation, endoplasmic reticulum stress, the epithelial-to-mesenchymal transition, Akt signalling and Wnt/β-catenin signalling, also participate in carcinogenesis, invasion or metastasis," the researchers explained, adding that prostasin has a known role in regulating these pathways.

That being said, they pointed out that prostasin may possibly mediate the process from hyperglycemia to cancer or may act as a marker for cancer susceptibility in those with elevated blood glucose.

"If a casual association were established in the future, prostasin may then be considered as a therapeutic target for treating both diabetes and cancer," Gunnar's group suggested. (emphasis added)

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MedPage Today Article is here:

Blood Protein May Help Predict Diabetes, Death From Cancer — Prostasin commonly found in epithelial cells of organs, by Kristen Monaco, Staff Writer, MedPage Today, August 4, 2022 medpagetoday.com/primarycar...

Full research paper is here:

Plasma prostasin: a novel risk marker for incidence of diabetes and cancer mortality, Diabetologia: Clinical, Translational and Experimental Diabetes and Metabolism, Published: 04 August 2022 -

link.springer.com/article/1...

And what ScienceDirect has to say about Prostasin (From the first article, note the 20x higher concentration in the prostate & seminal fluid than any other tissue.):

Prostasin - an overview / ScienceDirect

sciencedirect.com/topics/me...

Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay - Proceedings of the National Academy of Science, April 4, 2016, 113 (16) 4482-4487

pnas.org/doi/full/10.1073/p...

And Info on the Horvath Clock:

Steve Horvath (shorvath at mednet.ucla.edu)

horvath.genetics.ucla.edu/h...

The underlying message is to avoid insulin resistance at all costs - and continue to Stay Well,

Ciao - K9 Terror

[NPfisherman]

K9 Information Terror,

I do hope I remember correctly as I read post birthday cake. As I recall from the light reading, prostasin is down regulated in PCa. I did a search at Labcorp, but did not see a test offered--was it the cake messing up my search?? Monitoring levels over time when one is "undetectable" might give one a clue as to the direction one is headed...

This may be where Metformin may have a positive impact on PCa, but that is a Fish WAG, unlike a tail wag by you... It would help explain the potential benefit of Metformin in Pca by regulating blood sugar and prostasin levels.. STAMPEDE Arm K will likely decide if benefit or no benefit...

Thanks for the information...It gave me more to chew on, but not as tasty as cake...LOL...

DD