What should I expect to see PSA numbers after SBRT treatment?

[mike2344]

What should I expect to see PSA numbers after SBRT treatment?

[NPfisherman]

Hi mike2344

It depends on when you had the SBRT before the PSA test.... also, if you are on ADT or not... For me, I was on Lupron, Zytiga and Prednisone for 6 weeks before having SBRT... I went from 0.23 to < 0.03 in 6 weeks post SBRT...

Initially, if no ADT, then I would expect an upward spike because of PCa cell death from the SBRT in the first 6 weeks and a drop afterwards...

Because your profile is not completed, I can not be sure of your current drug regimen or history. Please let us know if you are oligometastatic ( < 5 lesions) and if that is why you had SBRT or if it is because of a spinal lesion...Also, if you could include where your lesions are located and we will answer you...

Don Pescado

[mike2344 in reply to NPfisherman]

Hi Don,

Thanks for your response. I was diagnosed with Prostate Cancer in Aug'18 with a Greason of 4+3 with 4 cores of 60% cancer (1 Core at Right Apex (D) and 3 cores at Right lateral anterior Pz (I). I finished 5 sessions of SBRT on 10/15/18.

Here are my PSA numbers:

10/19/19 (2.03)

7/19/19 (1.91)

4/16/19 (2.58)

1/21/19 (3.80)

10/19/18Finished SBRT treatment at UCLA

8/29/18 (7.84)

Any more comments are appreciated.

Mike

[NPfisherman in reply to mike2344]

Mike2344,

So if I understand correctly, you had SBRT to your prostate....you still have your prostate... and you are not on ADT... Is that correct?

There remain several questions...

1) Did you have a bone scan and CT scan before doing the SBRT or did you have the Axumin PET/CT scan before doing the SBRT?? The reason that I ask is because the Axumin scan is much more effective at picking up metastatic lesions than the bone scan or the CT scan... I had the bone and CT scans when my PSA began going up post robotic prostatectomy..and they were negative... My Axumin scan was positive for 1 lesion on my clavicle and that was when I started ADT and later had SBRT...

2) Have you had any recent scans--if so, what scans did you have and what did they show??

Don Pescado

[mike2344 in reply to NPfisherman]

Hi Don,

You are correct, I did not have ADT and I still have my prostate. SBRT is the only treatment I had, exactly 1 year ago today. I did have CT scan and MRI as part of the preparation for SBRT treatment.

I am 69 years old and am in good health.

Mike

[mike2344 in reply to NPfisherman]

Hi Don,

I forgot to mention that I had my SBRT at UCLA.

Mike

[NPfisherman in reply to mike2344]

OK...thanks mike

I reviewed your info and with a current PSA of 2.03 with your prostate intact, then you should continue monitoring PSA, stay in good health, exercise and do everything you are doing...continue f/u with Urologist and as indicated with the RO...

Good luck...

Don Pescado

[mike2344]

My prostate specialist doctor in California did not recommend ADT and I personally felt the risk of side effects may not be worth it. So, I decided not to get ADT. I decided against surgery early on.

Mike

[cujoe in reply to mike2344]

Mike, Nalakrats speaks the truth; i.e., lots of resources here. Never hesitate to ask/post any questions. Be Well - cujoe

[NPfisherman in reply to cujoe]

Indeed, many knowledgeable people here...able to respond and post......here... Life is Good...

Don Pescado

[j-o-h-n]

and good ones too....If i say so myself.... signed, SELF

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 10/23/2019 5:42 PM DST