Anyone know's if GDNF (Gene Therapy) is available?

[CV119]

I know there are clinical trials, but anyone know of actual therapies offered?

[goldiewan]

I have not heard of such a therapy. The trials require surgery. Some have suggested that fast walking or sustained cardio may raise GDNF levels in the brain. Also some evidence I came across somewhere that microdosing Iboga does that too. I have tried both of these things and they do help me quite a bit.

[CV119 in reply to goldiewan]

Can you share how you get Iboga? I'm not familiar with it

[goldiewan in reply to CV119]

Best to look up the Iboga thread in HU

[Boscoejean]

"GDNF clinical trials are experimental treatments for Parkinson's disease that involve delivering the glial cell line-derived neurotrophic factor (GDNF) into the brain. The goal of these trials is to restore brain cells that are damaged by the disease.

Trial results

Early results: Initial results from early trials were inconclusive, but some participants reported sustained benefits.

Brain imaging: Brain imaging data showed that GDNF had a biological effect in the brain.

Dopamine-producing cells: GDNF appears to help dopamine-producing cells to regrow.

Trial methods

Surgery: A custom-built device was surgically implanted into the brain.

Gene therapy: A new gene was delivered into brain cells using engineered viruses.

Ongoing trials

UCSF Clinical Trials: A trial that started in April 2020 and is estimated to be completed in June 2027

Ohio State University and Asklepios BioPharmaceutical: A phase 1 trial that found the treatment to be safe and well tolerated

Challenges

Some trials have not met their primary endpoints.

GDNF administration may require site-specific delivery.

GDNF receptors are expressed throughout the body."

cureparkinsons.org.uk/2019/...