Berberine’s Therapeutic Prospects in Parkinson’s Disease: A Spotlight on Cholesterol Regulation for Cognitive Improvement Oct 2024

[Bolt_Upright]

Berberine’s Therapeutic Prospects in Parkinson’s Disease: A Spotlight on Cholesterol Regulation for Cognitive Improvement Oct 2024 - ijper.org/article/doi/6034/

"Conclusion

Our study underscores the potential therapeutic utility of berberine in mitigating cognitive impairment in Parkinson’s disease. The findings presented here provide valuable insight into the mechanisms underlying the beneficial effects of berberine in Parkinson’s disease and suggest its promise as a therapeutic agent in managing cognitive deficits associated with this neurodegenerative disorder through regulating cholesterol homeostasis."

(I take 1200 mg a day)

[JayPwP]

Thank you Bolt!

Looks interesting, however it is a rat study. Also 40mg/kg rat dose, would be a very very high human equivalent dose.

[park_bear in reply to JayPwP]

An adjustment is needed to go from rodent dosage to human dosage due to different metabolic rate. For rats divide the dosage by 8, for mice divide by 12.

[Eryl]

The cholesterol myth has long been debunked. Cholesterol is essential to the body, it's how lipids are carried in the aqueous blood stream. Statisticaly, people with higher levels of cholesterol live longer. Cholesterol is made by the body so why on earth should anyone suggest that you have 'bad cholesterol'? What you can have is damaged good cholesterol and that damage is mostly done by high levels of blood sugar from eating too much carbohydrate.

Sugar is a majorcause of nerve damage so lowering blood sugar will help to reduce cognitive decline.

Berberine affects the beta cells in the panreas to increase insulin levels and hence lower blood sugar but it has side effects, which come from high levels of insulin so it's far better to adopt a ketogenic diet and not cause the high level of blood sugar in the first place.

[Bolt_Upright in reply to Eryl]

I think the "cholesterol myth" is the myth that eating cholesterol raises your blood cholesterol. I have harped on that myth for over 20 years. I am a big fan of salt and full fat dairy too.

There may be a myth about cholesterol in the arteries causing high blood pressure and heart disease based on the belief cholesterol is clogging arteries. Some people think the cholesterol is just attaching itself to damaged spots on the arteries to heal those spots.

We do have cholesterol in our bodies. Our bodies make cholesterol. I am not swearing by that article, but it's point, at least in the rats, was that berberine lowered the cholesterol levels in the brain and benefited some cells.

[Eryl in reply to Bolt_Upright]

Cholesterol is not blocking arteries as much as clumps of blood cells stuck to vessel walls and to each other with sugar. If you've ever cleaned tables after a party you'll know full well how sticky sugar is.

[MarionP]

Sugar is the bigger criminal here. However LDL (low density cholesterol) physically digs at and slides under the innermost cell wall cells of arteries, and the resulting bumps and beaks then attract clotting factors and they create clumps of blockage, atherosclerosis and arterial sclerosis and that increases blood pressure and blocks arteries. It is a major cause of heart attacks and need for cardiac bypass surgeries.