Compelling article on Mucuna Pruriens

[Rafiki2]

I have just come across this article on Mucuna which I would like to share.

Although it is a few years old and is quite lengthy, it is well written and makes for compelling reading, especially as it is well backed by several references.

intechopen.com/chapters/60608

[chartist]

This new 2024 human / MP study suggests that MP is quicker to take effect and longer lasting than C/L :

jstage.jst.go.jp/article/in...

Here is a relevant quote from the study :

' This is the first report of a pharmacokinetic analysis conducted on actual patients with PD showing that MP significantly prolongs the ON time. The advantages of MP as a treatment for PD have been confirmed: it is inexpensive, as effective as LD, works faster and longer than LD, and does not increase dyskinesia. '

Art

[eschneid]

Thal,. .........Many of us have been combining C/L and Mucuna for a long time with good success. I've been able to consistently count on Mucuna to time my dosing so I can enjoy life.

Curious Thal, do you take any supplements that helo you?

[eschneid]

Thal,.......,A few things wrong with your "angry, dis-satisfied with your life so you have to ruin things for others attitude."

First, you did not answer my only question if any supplements work for you-- as they are all treated the same here w/out FDA approval.

Also, pay attention Thal, as I already stated, I have been for a long time counting on its consistency to have a good qol.

While FDA approval would be great, there are some stringent manufacturing levels that must be met.

So, now that you've called people with parkinson suckers, please

tell us who in the medical field is paying you for your view on mucuna. Someone must be as it's clear you haven't done any research while many of us continue to live by this protocol.

[eschneid]

Forgot to ask Thal...... When you say, "Parkinson's patients are suckers for HOPEIUM," are you excluding yourself? Do you have Parkinsons? Why are you here?

[eschneid]

Thal,.......... Are you not listening. I've been taking it successfully for 10 years plus with no issues.. What part of that sentence do you still not understand?

[gomelgo in reply to eschneid]

In my experience, Thal has not been able to hear anything that contradicts his belief about mucuna. I refuse to engage with him on the subject because he becomes rabid to the point of gas lighting others who obviously receive benefit from it. mucunaparkinson.com/

[Meg024]

Yes, that article motivated me to start on mucuna and only take C/L for the sake of the carbidopa. 3,5 years later I'm doing well. With attention to 30-60 min a day of exercise, I have been able to gradually reduce my l-dopa from three doses per day to just two doses per day. Thanks for sharing. People need to know about this treatment that has been around for thousands of years. The toxic side effect that I experience is dyskinesia, however, from overdose of levodopa. Are there any studies that compare dyskinesia duration as a wearing off symptom from mucuna vs C/L?

[Rafiki2 in reply to Meg024]

Hi Meg,

One of the recommended methods to help Mucuna cross the BBB is to take just Carbidopa (without the Levodopa). Otherwise, failing this, one then needs to take a much higher dose of Mucuna. However, Carbidopa on its own is not available in every country and I have been unable so far to find it here in South Africa. Besides, it is still a synthetic medication.

An alternative is to take Mucuna with green tea as this too helps. I am instead using Matcha powder which is a much more potent type of green tea (up to 10 times better than green tea). I am filling the Matcha in capsules and have started giving my wife a capsule of Matcha with a capsule of Mucuna. This is 6 times a day.

She was already taking a teaspoon of Match in the morning, but will now be taking it every time she takes a Mucuna. Apparently, one can take 2 to 4 tablespoons of Matcha a day quite safely. Hope to be reporting on this favourably in the next couple of weeks.

In the meantime, she has reduced her C/L intake from 7 pills down to 3 over the past couple of months (doing this very gradually) and without any apparent problems. The one noticeable improvement so far has been a vast reduction in hallucinations. My wife does not have dyskinesia.

[drichardson12]

I have been on the amino acid (Macuna) treatment for 5 years. No meds and works good for me.

[debmorris1 in reply to drichardson12]

That’s wonderful! Can you give us more specific details such as how much how often and what do you take it with or what do you add to it?

[kevowpd]

The forum's naturalist ideologues are never willing to address the following insurmountable challenges when suggesting that PWPs should attempt to replicate the results from these studies that suggest MP is as effective as CL.

MP seeds ground after roasting

11 g of MP reagent

This isn't viable for >95% of PWPs.

[eschneid in reply to kevowpd]

Just curious where your 95% or greater number comes from. Just a curious natural ideologue here.

[kevowpd in reply to eschneid]

Are you roasting the seeds yourself and taking 11 grams per dose? Given that you've already said that you are combining CL with Mucuna, I doubt it?

To answer your question, in my time on PD forums I've obviously seen thousands of PWPs describe in detail their treatment regimen. In that time i can recall seeing only one poster - the lady who goes by the name 'Aunt Bean' (or similar) - who reported being able to persevere with a start to finish mucuna approach in a sustained way - i.e doing at least what is described in this paper and those like it.

Frankly i'd bet the number is higher than 95%, otherwise we'd consistently have people reporting that they are undertaking this approach and from what I can see, we don't.

What percentage of PWPs do you think are roasting their mucuna seeds then consuming 11 grams of the output for every levodopa dose they need?

[glassman1]

jnnp.bmj.com/content/75/12/.... ncbi.nlm.nih.gov/pmc/articl...

[Grey_Area]

"Compelling" is a good word. I tried one tablet of Mucuna, from a reputable source...and was compelled to vomit more violently than I have ever known for the next four hours.

[gomelgo in reply to Grey_Area]

It's not for everyone. Just like C/L isn't.