TREEFROG PRESENTS DATA FROM THEIR PARKINSON'S DISEASE CELL THERAPY PROGRAM ON PARKINSON'S DISEASE AND RELATED DISORDERS (IAPRD) IN LISBON

[Farooqji]

In pre-clinical models, full behavioral recovery was observed by 16 weeks post transplantation and dopaminergic neurons were seen projecting into the host striatum."

The off-the-shelf therapy in development by TreeFrog uses their proprietary technology, C-Stem™, a breakthrough technology that addresses critical challenges of producing high quality, cell therapies at scale, efficiently. The closed system enables both the amplification and differentiation of cells. The Parkinson's program is the first application of this technology using induced pluripotent stem cells (iPSC) that are differentiated into ready-to-graft 3D microtissues containing mature dopaminergic neurons.

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[Farooqji]

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[BH68]

That's positive news - thank you for posting

[curlscurls]

That sounds wonderful. And effective way to produce the cells is a great starting point.

I've heard two complaints from doctors about injecting cells.

1. That they're not programmable to turn off, so you can wind up with tumors. One doctor said that referencing studies in 2014.

2. That they inject in our healthy but then deteriorate in the same way the original cells do. Personally I don't see the problem, so reinject again when needed.

Does It look like this addresses either? Doesn't seem like it's related to what it's solving.

[Gallowglass]

Do the pluripotent stem cells come from Embryos or somatic cells?

[Smittybear7]

is this being done in US? Interesting- Thanks for sharing.Interested in updates!

[Farooqji in reply to Smittybear7]

It's in France

[Smittybear7 in reply to Farooqji]

Thanks

[evenshoshan in reply to Farooqji]

TreeFrog Therapeutics, 30 Avenue Gustave Eiffel, Bâtiment A, 33600 Pessac, France.

Just to the south of Bordeaux.

treefrog.fr

[LeharLover62]

With a little digging it looks like the “full behavioral recovery” refers to curing rats at this point with the stem cells.