new drug: youtube.com/watch?v=NdXQQ10... - Cure Parkinson's
new drug
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Look it up in you tube
Newly approved Parkinson’s medication helps mum regain mobility | 9 News Australia
OK, got it.
Newly approved Parkinson’s medication helps mum regain mobility | 9 News Australia
So this is the subcutaneous pump. I had not expected it to more effective than pills, but apparently can be amazing in 50% of the cases (per the video).
It should be better
It wont have fluctuating levels like oral one
Like insulin pump which has much better control on insulin dependent diabetes
I know a man in USA who has been on it for 3 yeras and states that his off time has reduced from 8 hours to one hour per day
3years, I thought it was new?
'It wont have fluctuating levels like oral one' - which is much truer than I ever imagined. So many things can negate our meds on the way to the intestine - in my case many many many foods - that I don't understand how a neurologist can say what is a high dose. I may take more meds than you but less may reach my intestine uninhibited.
it should be a lot better than pills. oral levodopa destroys gut motility. PD patients avoid protein due to timing issues. Malnutrition is very common. Subq administration will avoid a lot of these problems.
Plus you will get a more consistent bolus of dopamine administration, including at night. Dopamine in the healthy follows a circadian rhythm which peaks at night and troughs at midday, pretty much the opposite of people who take oral C/L.
It's going to be huge.
Yes, HUGE... at 62,000 Canadian dollars a year, it will break their health care system.
Says special formulation of Levodopa, I wonder if they add stuff to keep it from being changed to dopamine in the body. I believe dopamine in the body is responsible for most of the side effect of C/L.
Will be interesting to see if she develops side effects.
Has anyone watched the movie "Awakenings". Really Awesome that people in a comatose state where awaken after 30 yr only to develop dyskinesia from high dose levodopa. I had tears in my eyes when they were awakened. The movie never mentioned that after only one summer that their dyskinesia was cause by the levodopa. Based on A True Story (I wonder if in 1990 they knew of the side effects.)
"I wonder if they add stuff to keep it from being changed to dopamine in the body"I rather imagine that's the reason it contains carbidopa
At the time I doubt if they added carbidopa. The true story was I think the early 60's.
FYI: ... Lewy bodies can also cause Lewy body dementia. An autopsy three months after Williams' death showed he had this, rather than Parkinson's disease. "Clinically he had PD, but pathologically he had diffuse LBD. The predominant symptoms Robin had were not physical—the pathology more than backed that up. cbsnews.com/news/robin-will...
I don't know where to start. I assumed your comment which I quoted, referred to the new subq product
did you mean 62K/year?
"oral levodopa destroys gut motility."
Link to evidence of this please.
this is well documented, see footnotes 25-39 here for a long list of published experiments:
journals.asm.org/doi/10.112...
Wrong twice over, at least. Destroy literally means: "put an end to the existence of" which is not the case here. What you have evidence for is that dopamine affects motility. As WTP points out, levodopa medication is not the same as dopamine.
are you really that pedantic?
IMO The context or situation that a PwP's gut is in is well described here by DR Bloom in this NoSilverBullet interview from minute 20:46.
There are a lot of posts today which muddle levadopa and dopamine. This is another. Dopamine slows gut motility, and cells in gut produce dopamine for that purpose. Levadopa /carbidopa is absorbed intact. And carbidopa inhibits the production of dopamine
it is available in Scotland but as stated it needs trained staff to be able to administer and monitor it!
just my guess, but the person in the video probably had absorption issues with the pill form. This is not a new drug, just a new method of delivery. But what the heck, it works, right!!?? She definitely improved!
This is not yet available in the USA
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