Dear colleagues, I am a 71 years old male diagnosed with PD 2 years ago, with a suspicion that symptoms were there 2 years prior to that. Started with Sinemet for 10 days but could not tolerate it and, since then, I am on 6 tablets of Sifrol 0.18 per day (2/2/2). This dose of sifrol improved my general symptoms by 90% but with balance and walking the improvement was approx 70% . I learned o live with it.
Approx 3 months ago, I noticed a decline in balance and walking. My neurologist asked to increase my dose by 50% to 9 tablets per day (3/3/3) which I did for 7 weeks with no improvement at all, so I went back to the old dose without consultation with the neurologist.
I an scared of facing further decline and would appreciate any advice or recommendation. From experience with this group, I noticed that the collective advice given may be equal,or even superior, to that of a medical specialist. Thank you all
Written by
michelbekhazi
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Hi Michel, I too had more or less the same symptoms, especially nausea. These symptoms are recurrent in pwp who use Sinemet. I'm not a doctor but I solved the problem by dividing the pill into two parts and taking them 30/40 minuti apart from each other. As they say, it costs nothing to try. I hope you solve the problem.
I forgot to tell you that even if it's half a pill, it can cause nausea if we're in the car, even just as a passenger. It does this to me. Therefore, unless I am driving, I alwais wait 30' to 40'.
I had complications with C/L medicine when I first started with no symptomatic improvements. I was tested for H-pylori and treated. Then the medicine began to work . I went from 40% of normal functioning to 85%Get checked . Google H-pylori and parkinson's for case studies
many tks for sharing, i will follow up on the H-Pylori test
I had nausea problems when I was initially prescribed Sinemet. I was taking the standard "instant" release version of Sinemet. When my neurologist, at that time, switched out half my Sinemet dosage to the "delayed" release version, my nausea decreased considerably.
I would try a very small dose of sinemet again , start small. The tablet brecks into half. maybe start with one half a tablet a day and when you have determined how long it lasts then you can go to two doses. etc. Yes it takes some getting used to , but I found it worth while . Drink lots of liquids and excess CD/LD will be removed.
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Mucuna Prereins
Sifrol ER 
DBS...feeling pressured & can't decide!
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