Selnoflast (or not) on board! New Trial

[Ctime]

Well friends,

I am sitting here on 6 hours of pharmacokinetic monitoring after taking two white capsules that may or may not be Selnoflast!

This is part of the long awaited Phase 1B, (first in PWP).

My guess is that many may want to know how I feel. Fine. No different but that is expected.

Selnoflast is one of several new drugs that hope to address the problem of neuroinflamation, a NLRP3 inhibitor that is already in phase 1 trial for ulcerative colitis. I had a long PET scan last week to get baseline data on my current neuroinflamatory state. One endpoint is to compare that to scan data at the end of the study to see if there is measurable evidence of reduction in inflammation markers. They have also done a ton of blood draws, Lumbar puncture and the usual (and to me unsatisfying) UPDRS.

The trial is only 28 days so there is essentially zero potential for personal benefit in the near term but it KEEPS THIS WHOLE ENTERPRISE MOVING FORWARD. ( as flawed as it may be!)

It is an intense month with weekly neuro visits and two cross country trips for the scans. I was very nervous last week but doing better now. I have a bit of a phobia about being slid into tubes but during the MRI I kept thinking that if THIS vibration does not jiggle the neurons to a new state, nothing will. Flawed but it kept me going!

If there is anything dramatic I will post.

Onward!

CTime

PS my trial coordinator who was also my coordinator for Buntenetap said they expect a preliminary readout very soon!

[redhawk1]

Hey Ctime! You are certainly at the tip of the clinical trial spear! If I recall correctly this trial is sponsored by Roche who a few years ago purchased a company called Inflazone (or some such name). Glad to hear that Roche has initiated the trial to see if this highly touted medication will help in alleviating this thing they call PD!

I was in a Roche clinical trial for 5 years. They do a thorough job in gathering the cohorts response to the trial med.

Thanks for taking part in this trial! Yes, let us know from time to time how this trial and you are progressing.

[Ctime in reply to redhawk1]

Redhawk1,

>tip of the clinical trial spear

Lets call if the front of the landing craft! There is m ore room up here for others.

You are correct, it is the Roche trial and they are moving pretty fast on it now it seems. I was told they are recruiting 40 to 70 people and when I was in New Haven at the PET scan they said a few people have already completed the study. Hopefully we get these results also in 2024 and then the recruitment of a much larger long term study.

Just took my first meds at home (work actually) so we will see if there is ANY discernable effect after a few days.

Thanks for the encouragement.

C

[Boscoejean]

Is this the clinical trial you are participating in?

classic.clinicaltrials.gov/...

[Ctime in reply to Boscoejean]

Yes, I am pretty sure that is it.

edit: yes, that is the correct trial. I am enrolled through my neuro in Denver who is part of the CenExel network. cenexelresearch.com/cns/ CenExel is a for profit company that provides study sites for clinical trials. Imperfect solution...

[Gallowglass]

thank you!

[ZebraDoodle]

fingers crossed for you and the study. Thanks for posting.