Excuse the expletive but I think were onto something here. Apparently it thrives in meat eating biome and does less well in plant based environments.
Bacteria have emerged as important pathobionts in the last few years and appear to be contributing factors in not only intestinal disorders but also in extra-intestinal diseases. This is exemplified by diseases such as Parkinson’s disease, where DSV appear to play a causal role in the formation of synuclein aggregates, a hallmark of PD. It also provokes the question of whether the association and involvement of DSV can be extended to similar diseases such as ALS, HT, or AD, where DSV may act as a common denominator in disease pathophysiology. Similarly, role of DSV in the development of atherosclerosis has been reported. Thus, mounting evidence suggests that DSV have multifaceted effects throughout the human body, extending beyond their influence in the gut. This also applies to all other intestinal and extra-intestinal diseases that are linked to gut microbial dysbiosis where DSV overgrowth may occur. While a few studies have revealed some cellular pathways by which DSV may mediate their effects, the underlying mechanisms of how DSV may affect these diseases remain largely unknown. Thus, future in vivo and in vitro studies should focus on determining the molecular mechanisms behind the effects of DSV on the host. As some DSV species appear to be more pathologically significant than others and because DSV isolated from patients have worse outcomes on recipient cells than the ones isolated from healthy individuals, it is critical to understand the structural (such as LPS), biochemical, and functional differences between DSV species. This may hold a key to identifying the target mechanisms that are unique to each of these species. It is also important to understand what host factors in patients (but not in healthy controls) may lead to increased pathogenicity of these strains. Overall, this information may be helpful in identifying novel therapeutic targets that could be utilized in the management or treatment of diseases that are associated with DSV bloom.
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