Coming full circle?

[kaypeeoh]

<<<<<<Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood–Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice

Abstract

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by multiple hallmarks including extracellular amyloid (Aβ) plaques, neurofibrillary tangles, dysfunctional blood-brain barrier (BBB), neuroinflammation, and impaired autophagy. Thus, novel strategies that target multiple disease pathways would be essential to prevent, halt, or treat the disease. A growing body of evidence including our studies supports a protective effect of oleocanthal (OC) and extra-virgin olive oil (EVOO) at early AD stages before the onset of pathology. In addition, we reported previously that OC and EVOO exhibited such effect by restoring the BBB function; however, the mechanism(s) by which OC and EVOO exert such an effect and whether this effect extends to a later stage of AD remain unknown. In this work, we sought first to test the effect of OC-rich EVOO consumption at an advanced stage of the disease in TgSwDI mice, an AD mouse model, starting at the age of 6 months for 3 months treatment, and then to elucidate the mechanism(s) by which OC-rich EVOO exerts the observed beneficial effect. Overall findings demonstrated that OC-rich EVOO restored the BBB function and reduced AD-associated pathology by reducing neuroinflammation through inhibition of NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome and inducing autophagy through activation of AMP-activated protein kinase (AMPK)/Unc-51-like autophagy activating kinase 1 (ULK1) pathway. Thus, diet supplementation with OC-rich EVOO could provide beneficial effect to slow or halt the progression of AD.>>>>>>>>

It's a 4yr old rat study which means it's ancient by my hypochondriac standards. But the Mediterranean diet had long been touted for health and olive oil's effect on the BBB may be the reason. So now I gotta find true extra-virgin olive oil to add to my morning oatmeal. I recall 10 years ago that olive oil goes rancid quickly and the remedy is emptying a couple of vitamin E capsules into the bottle.

[Bolt_Upright]

Here is our post on most olive oil being fake and how to get the real thing: healthunlocked.com/cure-par...

[Baron1]

Best do some research to satisfy your personal needs.

In my opinion you need to find brands for quality and tested for the following:

1. Polyphenols

2. Oleuropein

3. Oleocanthal

4. Oleuropein Aglycone

5. Hydroxytyrosol

Extra Virgin Olive Oil that you purchase should be of the "Koroneiki" variety; which produce high levels of polyphenols.

Brands I would recommend:

Oligen 5mg Oleocanthal

Masworth.co.uk

Terra Creta - Grand Cru Extra (This is the one that I have purchased and has won multiple awards).

Hypereleon Ultra Gold

Morocco Gold

There is a web site EVOO World Rankings of extra virgin olive oils.

evooworldranking.org/_EN/in...

Best Wishes

[Dabaa in reply to Baron1]

Thanks for troubling to provide this great info. May I ask where exactly did you purchase the Terra Creta - Grand Cru from in the UK? Thank you very much.

[Baron1 in reply to Dabaa]

Good Evening,

I purchased from Amazon.

amazon.com/Terra-Creta-Gran...

However, if you reside in the United Kingdom, or surrounding countries you can try this website:

shopitlocal.co.uk/product/g...

Best Wishes

[Dabaa in reply to Baron1]

Thank you so much.

[Esperanto]

Olive oil is an important part of our diet and certainly for PD. As Bolt_Upright already mentioned, this item has already been posted by him recently and discussed in detail. It can be practical to bundle new EVOO information or questions there.

healthunlocked.com/cure-par...