This Very Brief Article May Be Of Interest For Anyone Thinking Of Using Nicotinamide Riboside Sometimes Referred To As A NAD+ Precursor

[chartist]

showme.missouri.edu/2022/in...

Art

[Bolt_Upright]

Thanks Art. I had heard about NR and cancer. I did some Googling and found all the NR and cancer stories come from the same research that came out last fall. Knowing all the cancer reports I have seen are all from the same study makes me feel better about NR.

[chartist in reply to Bolt_Upright]

Yes, full disclosure is useful, but all the data was not just from that study. Another previous study suggested that there might be risk of cancer:

ncbi.nlm.nih.gov/pmc/articl...

Art

[jimcaster in reply to chartist]

Not surprisingly, Dr. Charles Brenner, chief scientific advisor for Chromadex (Owner of TruNiagen) disputes the TruNiagen-Cancer link. Perhaps more importantly, Dr. Charles Canto, one of the authors of the study in question, also says the headlines suggesting the cancer link are "clickbait" and "totally inaccurate from a scientific standpoint."

raisingnad.com/does-vitamin...

[chartist in reply to jimcaster]

Jim,

Here is the study I found with the name , "Carles Canto" as one of the research team.

pubmed.ncbi.nlm.nih.gov/363...

Here is a quote from the abstract :

' Our results demonstrate that NR supplementation results in a significant increase in cancer prevalence and metastases of TNBC to the brain. These results outline the important role of powerful nutraceuticals like NR in cancer metabolism and the need to personalize their use in certain patient populations. '

If the article you linked to is correct and true, what researcher, puts their name on a study and then calls the study click bait? What does that say about the integrity of the researcher if he is willing to put his name on a study that he feels is nothing more than click bait. It seems like a researcher with any integrity at all, would never allow their name to appear on such a study.

The article you linked to didn't even link to the study itself, but rather just referred to it. If they felt confident in their statement, they should have linked to the study .

Art

[Bolt_Upright in reply to chartist]

I think the reason they called it click-bait is that the title of the study was "A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism" while the the title of the article was "Does Vitamin Supplement Nicotinamide Riboside “NR” Increase Cancer Risk?"

[chartist in reply to Bolt_Upright]

Bolt,

The point I am making to Jim, because he brought that article up, is mainly about the quality of such an article and the integrity of the researcher that put his name on that article and study and then described the study as clickbait.

As regards the study, it showed what it showed with the methods used and outlined in whatever their study design was. Canto had to see the study design before he signed on to be involved in it. If he was in disagreement with the study design, then why did he involve himself in that study or if he realized after the fact that the study was bogus, why did he not have his name removed from the study. There is such a thing as credibility.

The title asked the question and their quote from the study answered that question. It may be right or it may be wrong, we don't no for sure.

The doctor who was introduced as "the leading authority on NR" said this :

' in previous studies—including large human trials—B3 supplementation has been cancer preventative ',

but he didn't link to any of those studies. I will look for human cancer studies utilizing NR as part of the treatment protocol in humans, but I am very doubtful I will find them. Just saying this stuff in articles doesn't mean it is true. Linking to at least one of the studies he was describing of cancer, NR and humans would have added credibility to his statement, but he didn't do that. Yes, nicotinamide/niacinamide have shown some cancer benefit for skin cancer, but what about NR, which the article is about?

I brought the study up in the first place because I know that NR is regularly discussed on HU and I think it is useful to be able to weigh all of the information available about it in making a decision to use NR.

Art

[Bolt_Upright in reply to chartist]

Thanks. This is good information. I think the click-bait part was putting "cancer" in the title.

Another good point you raise is that line ' in previous studies—including large human trials—B3 supplementation has been cancer preventative'.

There are 4 forms of B3: niacin (nicotinic acid) and 2 other forms, niacinamide (nicotinamide), inositol hexanicotinate, and the new kid: NR.

- These 4 forms act differently in the body so the article should not be lumping them together.

Personally, I am sticking with Nicotinic Acid, 1000 mg twice a day. Maybe it is because I am cheap.

[Gioc in reply to Bolt_Upright]

Bolt_Upright,

B3 NA nicotinic acid o niacin boost NAD via de-novo which is IMO the safest route as long as there is gradualness and good nutrition rich in minerals and vitamins in proportion to niacin so as to give time and nutrition to the complexity of the processes induced by the de-novo path in the creation of Nad.

In other words, take it easy, a good but light Mediterranean diet with few sugars and complex carbohydrates, very varied, fresh fruits and vegetables for minerals, a lot of movement and Physical exercises and go up very gradually with the b3 NA nicotinic Acid, it take months,

QUOTE:

“A prominent pathway in NAD production is a de novo process; as a result, numerous steps are required along the NAD production pathways by numerous precursor molecules for biosynthesis. Nicotinamide being an amide of nicotinic acid must undergo multiple reactions along this pathway in order for the NAD molecule to be synthesized, which opens up numerous possibilities and discussions for the deactivation of NAD synthesis when cancer is present. ”

ncbi.nlm.nih.gov/pmc/articl...

[Baron1 in reply to chartist]

Bravo, thanks for the post.

[park_bear in reply to chartist]

I think it was good to post this study as a heads up. This study covers metastasis of a particular kind of cancer. Is it true for other cancers? Maybe but we really don't know from this alone. On the other hand there are numerous studies showing Niacin reduces skin cancer risk. Admittedly this is a different form of vitamin B3:

scholar.google.com/scholar?...

Be that as it may, the information that we have at hand so far is scant and mixed - not ready for a conclusion in my opinion.

Now let us compare to the folate situation. As I set forth here: tinyurl.com/ycdrz5lj -we have two different epidemiological studies and an interventional study all showing folate supplementation substantially increases cancer rates. The interventional study of folate supplementation resulted in increased prostate cancer risk by 2.4 times.

[Gioc in reply to chartist]

Interesting study Art! (This last one)

However, cancer, PD or earthquake the important thing is to survive.

Greetings from Italy.

Gio

[Bolt_Upright in reply to Gioc]

Is that a picture of you Gio?!

[Bolt_Upright in reply to chartist]

Thanks Art, I had seen this other study "Nicotinamide adenine dinucleotide and the sirtuins caution: Pro‐cancer functions" ncbi.nlm.nih.gov/pmc/articl...

It is not about NR but about the risk to boosting NAD in itself: "Further research into whether elevating levels of nicotinamide adenine dinucleotide or overexpression of sirtuins can increase the potential for neoplasm or other age‐related pathophysiology is warranted due to the high energy requirements of certain diseases such as cancer."

[chartist in reply to Bolt_Upright]

NR is a NAD precursor and I think most people take it to boost NAD in order to get the reported benefits of NAD?

Art

[Bolt_Upright in reply to chartist]

Thanks. I guess my point was that this specific cancer warning applies to all NAD boosters, not just NR.

It is a good point though.

[Gioc in reply to Bolt_Upright]

Bolt_Upright , in my opinion it doesn't apply to any of the Nad+ boosters so simplified. Otherwise I could say that glucose or any cellular nutrition could increase the chances of cancer that it is already in the body,but that's not the case... maybe.😀💁

The point is well deepened here in this study and cannot be oversimplified.

ncbi.nlm.nih.gov/pmc/articl...

😀si sonoio.😉

[Bolt_Upright]

One more thing to consider: If you are taking NR because you think NR can treat PD, then an extra risk of cancer is probably negligible. It seems that every drug commercial I see says it might cause cancer (or worse).

[chartist in reply to Bolt_Upright]

I get that, but we are discussing a very specific study and researcher's comment. I'm not saying that NR causes cancer, I'm pointing out a study that suggest it might, and I think if you are thinking about taking it, you might want to be aware of it. I felt the article itself was a hit piece and lacking credibility, the way it was done and presented.

Art

[Bolt_Upright in reply to chartist]

I totally agree Art. I think it was a great article to share.

[chartist in reply to Bolt_Upright]

Bolt,

I sent you a chat message a little earlier, did you get it? It doesn't show in my chat messages, but if I click on your icon and select to send you a message, then I can see the message I sent, but can you? You're the only person this happens with that I have chatted with.

Art

[MBAnderson in reply to chartist]

That's because Bolt is a secret, (big pharma) agent.

[chartist in reply to MBAnderson]

Is this true, Bolt, you're a secret agent for big pharma????😆😆😆😆😆

Art

[Bolt_Upright in reply to chartist]

The chat function on this site is horrible. This time I did get your chat and I replied within 10 minutes and you did not get my reply

Here it is: "Interesting article Art!

I need to find my old post that linked to an article explaining how the different B3s worked differently to boost NAD+

This is all very complicated.

It makes sense. It is like these old guys that take testosterone. You speed old things up and the bad things get sped up too."

[chartist in reply to Bolt_Upright]

Yes it is very complicated, the relevant studies are scant and it is above my pay grade!

Art

[chartist in reply to Bolt_Upright]

Yes, I did not receive this reply in chat.

Art

[Sydney75]

Someone recently posted the same type of research about resveratrol. Didn't see how nicotinamide much the author's father was taking. Upper suggested limit for Nicotinamide is less than 900mg and for Niagen 300mg. Sometimes we take a break from supplements. too. Also, what else was he takinga and how could she specifically pin point this supplement. Most negative reports I read on supplements are combined supplements.

[Smittybear7]

Is taking b complex a concern?

[Boscoejean]

The comment made was that the supplement increases cellular energy so does that mean that any supplement that increases cellular energy could be an issue?

[chartist in reply to Boscoejean]

I don't think so, because melatonin increases cellular energy with increased ATP production, but it is only noted for fighting cancer through multiple mechanisms of action. CoQ10 also increases cellular energy , but is not noted for cancer.

Art

[Despe]

articles.mercola.com/sites/...

[chartist in reply to Despe]

I don't know what your link has to do with this subject?

Art

[Despe]

Sorry, Art. His post had a list of all the good supplements, however, his posts stay on only either 24 or 48 hours. Nothing to do with your post.

PS. He would be a good candidate, nevertheless.