carbidopa, levodopa and anal/rectal pain

[MissRita]

Hello all!

I know this might be a little bit of TMI for some of you, but I have to know if anyone of you out there has ever experienced severe anal/rectal pain from using carbidopa levodopa? Especially from the time you take it until the time it seems to start to work?

I have been on C/L since February 2021 and it’s basically the only thing that I can take (and I don’t take too much of it) after everything they had tried for the tremor/spasm failed. Now it seems like the tremor/spasm has either irritated or made my pudendal nerve worse (that is the area that is called the perineum or perineal area which I essentially nickname “the devils highway” lol) or it has begun to start to affect or irritate my anal/rectal area.

Additionally, a great deal of my tremor/spasm affects that lower region more so than anywhere else in my body.

Any information from anyone that has experience this would be greatly appreciated. Thanks.

[Sydney75]

I would get a micro nutrient blood panel completed you may be deficient in a key nutrient that C/L exacerbates.

[MissRita in reply to Sydney75]

what kind of test is that and what kind of doctor would do it?

[Sydney75 in reply to MissRita]

We used a functional medicine MD (she is also a internist). It was called a micro nutrient panel by The MicroNutrient panel by Specta Cell Labs, they are in Houston TX. You may be able to find a provider thru their website. We also did urine test thru Great Plain but start with the blood tests first. I think the cost was about $300.

Speak with your Neuro movement specialist too, not just your GP. This is a bit strange. You may benefit from some of the PD add-on meds to address this symptom. Also make sure you do not have another underlying condition that the PD has exacerabated.

I am not sure if the article below is what your symptoms are, it may be informative.

Anorectal Manometric Dysfunctions in Newly Diagnosed,

Early-Stage Parkinson’s Disease*

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/thejcn.com/Synapse/Data/PDF...

[Sydney75 in reply to MissRita]

We used a functional medicine MD (she is also a internist). It was called a micro nutrient panel by The MicroNutrient panel by Specta Cell Labs, they are in Houston TX. You may be able to find a provider thru their website. We also did urine test thru Great Plain but start with the blood tests first. I think the cost was about $300.

Speak with your Neuro movement specialist too, not just your GP. This is a bit strange. You may benefit from some of the PD add-on meds to address this symptom. Also make sure you do not have another underlying condition that the PD has exacerabated.

I am not sure if the article below is what your symptoms are, it may be informative.

Anorectal Manometric Dysfunctions in Newly Diagnosed,

Early-Stage Parkinson’s Disease*

chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/thejcn.com/Synapse/Data/PDF...

Hope it helps or leads you in the right direction.

[Sydney75 in reply to Sydney75]

sorry posted twice for some reason