citicoline or PEA?

[Divii]

I am struggling with delayed recovery of my symptoms (on time) despite taking c/l first thing in the morning. Dopamine agonists n selegiline not helping much too. I am taking 300 mg SR thiamine with magnesium n zinc. Tremendous fatigue, gait issues n stiffness. I take dopamine 100/25 two- three times a day in divided doses. MP didn’t work too. My Neuro ain’t a fan of supplements and I am very certain tht increasing c/l ain’t going to provide me any benefit. I sleep very poorly with no more than 30 minutes of deep sleep on an average.

Read a few posts about Citicoline n PEA. , mannitol or ambroxol or Berberine. Wondering if I should start on at least one of them for my symptoms. If yes, any suggestions which one should I go with?

thanks so much for guiding me!

[garygjs]

My mum's physical capacity - most particularly her gait - has improved very significantly with the addition of citicoline (4 x 250mg/ day). That improvement came very quickly...within 24hrs. We've been able to cut her levodopa dose (Sinemet CR) in half.

I've little to add about the others but have recently introduced PEA (Normast) and will happily report back.

Good luck.

[Divii in reply to garygjs]

any Particular brand you’d recommend ?

[CRMACK1948 in reply to Divii]

so sorry to hear about the challenges you are facing.My husband has a consultant who also can’t see beyond sinemet for treatment of Parkinson’s,and says any improvement must be a placebo effect.However,he started taking PEA 3 months ago,high dose 1,200 mg a day,and now starts on half that dose from now on.Everyone we know has said they see and hear a marked improvement in his speech and walking,though he still has balance issues.A company called OptiPEA who manufactures pure PEA has a list of authorised stockists ( they are in the Netherlands) They are very helpful if you email them.We also made a red light hat which he started to use about 5 weeks ago,which helps your brain to help itself,rather than more meds with nasty side effects.Parkinson’s can be a lonely journey,symptoms and remedies vary from person to person,and I hope you can find what works for you.You also mentioned lack of sleep,which can effect everything else.We got melatonin tablets from the US( you can’t buy them over the counter in the UK) and 10 mgs plus a magnesium tablet about 1 hour before bedtime has made a tremendous difference to his sleep pattern,now he gets 5 to 6 hours,whereas before it was 3 hours of broken light sleep.

[garygjs in reply to Divii]

We use Cognizin citicoline...made by Kyowa and sold by Mind Nutrition in the UK.

If you input "Cognizin" into Google Scholar you'll see that it's been used in a number of trials.

It's not especially expensive compared to peers.

[Marcia123]

is acetylcholine good or bad for Parkinson’s I take amantadine, which is an anti-cholinergic and my muscles and that is all going away

[LauraYu in reply to Marcia123]

I think it depends on the person, as everyone is different. I tried citicholine before, and found that my tremors and stiffness were worse, so I stopped it. I am also on amantadine, it works at beginning but the improvement started fading away , I feel so weak. I had to add vitamin D and calcium , and vitamin B complex. I am better now, still trying to figure out what kind of B complex fits me

[Marcia123 in reply to LauraYu]

do you take other Parkinson’s meds such as levodopa carbidopa?

[LauraYu]

I take Sinemet 25/100, 1.5 pills twice a day. I don’t take it after 2 pm, to avoid dyskinesia and give my body a chance to run by itself. My dyskinesia is so bad and last so long each time, the benefits of taking Sinemet is not long enough compared with its cost of the dyskinesia

[TL500]

Either PS128 by itself or with Restore Gold seem to help me sleep better.