Autophagy proceeds in five main steps: (1) autophagy initiation, (2) phagophore formation, (3) phagophore expansion, (4) fusion with lysosome, and (5) degradation by lysosome.
Lot's of informative info in here: Pharmacological insights into autophagy modulation in autoimmune diseases 2021 sciencedirect.com/science/a...
And here is a cautionary note from another publication: "However, the effective therapeutic use of autophagy induction requires detailed knowledge of how the disease affects the autophagy-lysosome pathway, as activating autophagy when the pathway cannot go to completion (e.g., when lysosomal degradation is impaired) may instead exacerbate disease in some cases". Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases 2020 pubmed.ncbi.nlm.nih.gov/318...