Practically every neurologist I've encountered is pretty firm on the point that meds should be taken on the same daily schedule at the same dosages.
This recommendation is something I haven't always adhered to and I think I've had some decent results in not getting with the program. When I was still working, I often had classes to teach between 9am and noon. When PD symptoms begin to worsen, instead of accepting the neuro's advice to increase dosages, I began front loading meds so that I would be at my best when I had to perform in front of groups. True, I slowed down later but not so much that I couldn't deal with what I considered less stressful activities like faculty meetings and office hours.
In short, at least for me, I don't see a lot of harm in doing some experimentation with dosages and timing. This is an example of not blindly accepting what the doc says and being a bit of an advocate for one's self.