Short answer: Once levodopa gets into your bloodstream (after being absorbed in your digestive tract), it doesn’t last long … most of it is gone after about 2-3 hours, and then you need to take more. The resulting rapid oscillations in blood levels of the drug are responsible for both on-off cycling and dyskinesia.
Longer answer:
Chart of immediate release and controlled-release plasma levels over time:
That is because the body gets used to it, and you need to take more of it to get the same result. The problem is that you soon start to get DYSKINESIA, which is even worse than the Pd. Why go that route if you can start getting better by doing High Intensity Aerobic exercise, which may sound impossible, but it isn't. Unless you have some other health condition that prevents you from walking then you can start getting better today!
Hi. Are there any links for recommended exercise regiment?
Thank you.
I don't want to start a debate, but our bodies don't "get used to it." As our condition deteriorates, we need more levodopa. It's also not true that we "soon" develop dyskinesia. As with virtually everything else with PD, the timing and severity of dyskinesia varies considerably from person to person. Some people never get dyskinesia.
The best way to create levodopa in your brain is to do fast walking. It produces more BDNF and GDNFwhich manage the production of LEVODOPA in thte partm of the brain that needs it. Se rgw Mayo Clinic study on the study thay carried out.
One person’s 10 year journey of taking Levodopa. How the amount has increased, the change in dosing intervals and how they manage it.
Why do I fall forwards? Somebody asked why I take Berberine. I figured it something good to share.
Why should I take extra vitamins
Hi my question is do I have Parkinson's
