Effects of melatonin prolonged-release on both sleep and motor symptoms in Parkinson's disease: a preliminary evidence.

pubmed.ncbi.nlm.nih.gov/355...

Results: Sleep latency significantly decreased from T0 to T1, but no other significant differences were found in PSG parameters. Melatonin PR treatment significantly reduced the ESS scores from T0 to T1, while the PSQI scores presented a trend of improvement from T0 to T1. Motor dysfunction was not improved by melatonin PR, although there was a trend in decreasing UPDRS-III. Both clinical global improvement and patient clinical global impression documented an improvement in insomnia symptoms at T1.

Conclusions: These findings suggest that melatonin may improve sleep symptoms in PD patients, although further evidence is needed in larger controlled studies to confirm these results and explore the possible direct and indirect influence of sleep improvement on motor dysfunction.

[jimcaster]

2 mg seems like a small dose, but this is interesting.

[Kevin51 in reply to jimcaster]

I take 2 mg nightly and my Fitbit sleep scores have increased; deep sleep up almost. 50% . I take 100mg CR sinimet nightly as well. Try to time with my circadian rhythm.Best K