So... I speculate a lot. I started the Circadian Diet based on the knowledge that PWP have weak circadian rhythms. I should add that my RBD is getting worse, so either nothing is working, or some of the things I do are working against me. But I digress.
This study is about how if you restrict a mouse's calories AND only feed them during their active time (nocturnal) they produce more NADH during their resting time (day time). Maybe I can flip that and assume my circadian diet is producing more NADH at night?
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding Dec 13 2021 nature.com/articles/s42255-...
"Results presented here reveal that the circadian system participates in the response to a low-energy state associated with hypocaloric feeding through the rhythmic elevation of NADH during the daytime and inhibition of SIRT1 in liver. In nocturnal rodents provided a CR diet limited to the active period, we observed that daytime NADH elevation drives a daily drop in core body temperature in the morning, rhythmic inhibition of SIRT1, decreased BMAL1-dependent gene expression and reduced acyl-carnitine and amino acid levels. We speculate that NADH regulates energy conservation in the morning when food becomes scarce for nocturnal mice through the inhibition of SIRT1-controlled gene networks."
Is this a good thing? I don't know. I would think caloric restriction and eating in time with the circadian clock would be a good thing, but the links I am finding seem to say otherwise. I must be misunderstanding this. More digging is needed.
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Now... these folks seem to be saying Sirt1 activation is good for the circadian clock, usually, except when it is not, maybe: Impact of circadian disruption on health; SIRT1 and Telomeres Dec 2020 sciencedirect.com/science/a...
There is a lot of interesting stuff in that article. Here is the last paragraph: "In light of current knowledge, it is suggested that decreased expression and activity of SIRT1 may contribute to aging and age-related diseases by leading to telomere dysfunction/shortening, and the impaired circadian clock. Therefore, one would suggest that Mg2+ /SIRT1 combination may help quality aging."
"This review will examine compounds of natural origin recently found to upregulate SIRT1 activity, such as polyphenolic products in fruits, vegetables, and plants including resveratrol, fisetin, quercetin, and curcumin. We will also discuss the potential therapeutic effects of these natural compounds in the prevention and treatment of human disorders, with particular emphasis on their metabolic impact."
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