Naltroxone

[Joinifer]

Has anyone tried Naltroxone - it is a pain

relief drug. It is ordered from a pharmacy

Compounder

[ElliotGreen]

Hi, thanks for your question.

It is spelled Naltrexone.

I initially tried this medication at full dose (50 mg) in hopes that it would help me with compulsive Internet use (it helps with opiate addictions and alcoholism, some evidence of compulsive gambling). It didn't really seem to help that for me.

However, since I have it on hand, I've recently tried it in its low-dose form. I dissolved half a tablet in 25 mL of distilled water. I put it in a small spray bottle I have (for intranasal application, but I just spray it onto my tongue). I counted the number of pumps per milliliter. By counting the number of pumps, I can take 2.5, 3, or 4 mg, etc. I keep the bottle in the refrigerator.

LDN (low dose naltrexone) actually modestly increases endorphins (if you take it at night, your endorphins are increase the next day).

I do notice a moderate positive effect on my mood and motivation. I don't know if it helps with inflammation (a probable underlying factor in the progress of Parkinson's disease), but I think it should.

Some people and studies also suggest as a treatment for pain. Your query was the first I'd heard of that, but lo and behold:

The Safety and Efficacy of Low-Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders

pubmed.ncbi.nlm.nih.gov/293...

[Joinifer in reply to ElliotGreen]

My pain doctor recommends 4 mg for pain relief. It works the best of anything I have tried in the last 3 years.

[samhill]

I hope you find this helpful. We have just started my sister in law on LDN. Encouraging info: fight-parkinsons.org/wp-con...

[Bolt_Upright in reply to samhill]

Great link. Thanks!

[HugoRipanykhazov]

Interesting article but it left one point slightly open.

Does LDN treat one subset of PD patients, those whose disease derives from an autoimmune condition?

OR are all Parkinson's patient's conditions derived from some sort of autoimmune condition to some extent or other?

(I have never heard it suggested that myPD derives from any sort of immune system deficiency)

[Joinifer]

I use Naltrexone for pain relief not for PD. My pain doctor could not relieve the pain in my necksimilar to occcipital neuralgia. I had 4 nerve blocks w/no success. Also, I have nerve pain in both

feet after surgery to remove a neuroma in each foot. I have very sensitive nervea I had trigeminal

neuralgia 15 years ago