Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease 2021

[Bolt_Upright]

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease mdpi.com/2227-9059/9/11/167...

This is an open access article.

Abstract

Mounting evidence suggests that ferroptosis is not just a consequence but also a fundamental contributor to the development and progression of Parkinson’s disease (PD). Ferroptosis is characterized as iron-dependent regulated cell death caused by excessive lipid peroxidation, leading to plasma membrane rupture, release of damage-associated molecular patterns, and neuroinflammation. Due to the crucial role of intracellular iron in mediating the production of reactive oxygen species and the formation of lipid peroxides, ferroptosis is intimately controlled by regulators involved in many aspects of iron metabolism, including iron uptake, storage and export, and by pathways constituting the antioxidant systems. Translational and transcriptional regulation of iron homeostasis and redox status provide an integrated network to determine the sensitivity of ferroptosis. We herein review recent advances related to ferroptosis, ranging from fundamental mechanistic discoveries and cutting-edge preclinical animal studies, to clinical trials in PD and the regulation of neuroinflammation via ferroptosis pathways. Elucidating the roles of ferroptosis in the survival of dopaminergic neurons and microglial activity can enhance our understanding of the pathogenesis of PD and provide opportunities for the development of novel prevention and treatment strategies.

[park_bear]

Excess iron known to be detrimental in PD

[MarionP]

Very interesting.

[Thal]

Interesting that the new med I'm on "entacapone" is also a COMT inhibitor to help dopamine level and inhibits ferroptosis. It helps with cancer also.

youtu.be/UQsjppCZQCQ?si=OYZ...(Not working as expected?)