Has anyone tried reuteri probiotic - Cure Parkinson's
Has anyone tried reuteri probiotic
Caution Advised, this indicates we may want to avoid taking reuteri: The oral microbiome of early stage Parkinson’s disease and its relationship with functional measures of motor and non-motor function journals.plos.org/plosone/a...
Specifically, Lactobacillus reuteri, which we found significantly increased in our PD subjects, was shown in a prior study to increase alpha-synuclein release in cultured ENS neurons, presumably due to increased firing of mesenteric afferent nerve bundles (caused by decreasing calcium-dependent potassium channel opening and reducing the slow afterhyperpolarization in these neurons) [43–45]. In this light, it is particularly worthwhile to note that our exploratory correlation analysis identified a robust positive correlation between the abundance of Lactobacillus reuteri and slowing of movement (as reflected in increased performance time on the Trailmaking A test) (Table 6). Other evidence also suggests that Lactobacilli might not be particularly beneficial in PD. Specifically, some members of this bacterial family have been shown to reduce ghrelin secretion, which normally regulates nigrostriatal dopamine and is thought to be neuroprotective, and has been previously reported to be reduced in PD patients [46, 47]. Thus, based on the available data, the consistent increase in Lactobacillaceae we and others have observed in PD may represent a disadvantageous yet consistent event in the disease. This suggestion contrasts with much current opinion regarding Lactobacilli. Indeed, administration of Lactoballicus reuteri has been shown to reduce anxiety and corticosterone secretion in mice [48], and several other Lactobacillus species have proven beneficial in the treatment of constipation, diarrhea, and IBS symptoms [49] (see Table 7). Accordingly, we suggest that a closer examination of the benefits and risks of Lactobacillus supplementation is warranted.
Thank you 🌸
R u going to try ps128 probiotic, mentioned here? I'm wondering what pre/probiotics we have to much/less of.
I don't have any plans to start PS-128. I don't have anything against it, I just want to reduce my stack and I have a lot of players I think may be beneficial: B1, BCM-95, Selenium + Inositol (for my Hashimoto's), Vinpocetine, Saffron, Niacin TR 300 MG, NAC + Taurine, Nigella Sativa, Ceylon Cinnamon, Magnesium, Matcha Tea, Mannitol, Broccoli Sprout Tea, Coconut Milk smoothies with resistant starches. I also take a few things a couple times a week: Vitamin D, E, Cod Liver Oil, B12 and MSM. I still take Sodium Butyrate once a day. I think it is good for the microbiome. Not sure Sodium Butyrate is the best form of butyrate. And I have a few things I take just because I bought them and figure they may help and I need to get them out of my stockpile: Bio-Kult. And I have some Lion's Mane but it seems to trigger my REMSBD so I'm kind of wary of it.
Thank you
Butyrate, not worth trying? Thank you.
I KNEW I should have been careful there. Butyrate may well be worth taking. I may end up keeping it in my stack. May help fix the microbiome.
😀
Also, cinnamon ?
@park_bear believes in Cinnamon and I do too. I don't believe in it because I can tell it helps, but I trust the logic behind it (and my sense of smell is back, but I take so much, who knows why).
I've completely lost smell and taste,since last month. I don't know if it's Parkinsons or I might have had covid, my son had it, A- systematic, the rest of us mild symptoms
Hubby alternates between several including b subtilis and Reuteri. Honestly I’m not sure if they’ve helped anything though.
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