Has anyone had any experience with Amantadine just been prescribed by my neurologist to help with moderate tremor.

[Bramma]

Amantadine

[Juliegrace]

If you do a search there are many posts including one from a few days ago that should answer your questions.

[Bramma in reply to Juliegrace]

Ok thanks

[ParlePark]

It worked for two years then stopped working. I’m now on C/L and works very well.

[eschneid in reply to ParlePark]

It did not help me with tremors since I started 100 mg two or three months ago, but it stopped my mild dyskinesia. No side effects that I am aware of at this time.

Eric

[Bramma in reply to eschneid]

Thanks Eric

[Williemom]

Our daughter has been taking Amanda as she calls it for about a year now. It helps her dyskinesia but has caused what they call, Livedo reticularis a type of mottling of the skin on her legs and arms. Looks like a red lace on your skin. She co tiniest to take the Amanda since it helps her condition but is concerned about the “mottling”…..another word for it, she takes one Amandatine (not sure of the mg) and one gabapentin mid morning to keep her dyskinesia under control. Hope this helps. However, as I am always reminded……no 2 PWP are the same or respond the same to medications.God bless. ❤️🌸🌺🌻

[Bramma in reply to Williemom]

Thanks for your comments

[Shaky-hand]

I have been taking 100mg of Amantadine twice a day for three years now. It has helped control my tremor so that I can do so much more with my right hand. About two years a go I noticed a deterioration in my vision requiring strong reading glasses to read even large sized print. I have since read that Amantadine can effect your vision. Eighteen months ago I developed Livedo Reticularis firstly of the legs then it began in the arms. My MDS doctor told me to stop taking it. I had done some earlier research that advised users to wean slowly off the drug and do not stop it suddenly.

I have attempted three times to slowly withdraw over a month then over two months and each time I get down to a low level I feel terrible and I am no longer able to function. I go back to taking it and feel good again.

I was diagnosed with tremor dominant PD in 2010. The first six years I did not take any medications and was able to continue working. I had to take early retirement in 2016 because I also developed severe back pain with radiating pain down both legs. It was the straw that broke the camels back. I struggled to work with PD but was determined to continue. This probably placed a huge strain on my back.

I am unable to tolerate C/L because of left leg dyskinesia with the second 1/2 tablet, vomiting and nausea plus wanting to sleep all day. I’ve tried extended release and various doses and I get no good effects only side effects.

I was taking Selegiline for years, 5mg, two times a day. Seemed to give me more energy and no side effects, or so I thought. I stopped taking it a month ago when I found that it could have caused the dilation of my common bile duct and intra / extra hepatic ducts, seen on a spine MRI. Doctors were concerned about malignancy especially when the tumor markers were elevated. After MRI and CT of the abdomen and thorax, plus a PET scan, ( I had a lung mass and pelvic masses too) the PET/CT was negative.

Consulting with the GI specialist he said the dilation of the ducts was caused by the. Codeine and Tylenol I take for pain management. Research showed that Selegiline interacts with the Codeine and Tylenol to exaggerate its toxicity to the liver.

Sorry for the lengthy reply.

Karen

[Bramma in reply to Shaky-hand]

Hi Karen,I am 4 years in since diagnosis and have been taking levodopa for about a year, it doesn’t seem to help my tremor or stiffness in my right arm. I have recently experienced lower back pain which seems to extend down my hamstrings.

I guess my question is the only main symptom I have of pd is the tremor which is annoying but I can still work and play tennis would you advise taking Amantadine.

Thanks for your comprehensive reply.

Neil

[Shaky-hand in reply to Bramma]

Hello Neil,The Amantadine is the only drug that dampened my tremors. I use to take Selegiline for five or six years but found out recently can cause Liver problems if taking Tylenol for pain and/or Codeine. Selegiline apparently exaggerates the negative effects of these drugs. I had no difficulty in stopping Selegiline. Amantadine is the only drug I take for my Parkinson’s management.

I was initially fine taking Amantadine, no side effects for at least a couple of years. I then started getting greater blurriness of vision requiring much stronger reading glasses. There are studies that support this could be the Amantadine. About six months later I developed a lace patterned rash starting distally at the forefoot to the knees but a year later extends from foot to hip, both legs. This is a known side effect, Livedo Reticularis. The past six months I developed swollen feet and ankles. Also causes me a dry mouth and constipation and occasional acting out your dreams.

I have tried stopping it for the past year. Per my doctor, “just stop taking it, you will be fine”. I felt awful following the first missed two doses. I was shaking aggressively that made me anxious and that increases the stiffness. I could barely function. I felt really ill the next day and was running a low grade fever, 99.9’F. This went on for three weeks.

My heart rate was high rarely going below 90 and sometimes being 125.

I went to the ER. Everything came back negative, I was healthy per tests.

I went back onto Amantadine and felt much better within 12 hours.

Research showed that sudden termination of Amantadine can lead to a Parkinson’s Crisis and many patients try but are unable to stop. Like me, I continue to use despite the adverse effects.

I do take Mannitol, daily since June 2013.

Vitamin B1 500mg (I am petite) daily.

Melatonin 20mg nightly.

Apologize for lengthy reply, can’t seem to keep it brief.

Karen.

[EnterTheDragon]

Within two hours of taking my first dose of amantadine, I had severe chest pains and my heart started racing. I actually fell to the floor and was ready to call 911. That was my first and last experience with Amantadine.

[Bramma in reply to EnterTheDragon]

I had the same experience with Rasagaline i think that’s what makes me nervous with new meds. Thanks for your comments.

[Ewalt]

My husband is on this medication and can say it has reduced his dyskinesia. I am so grateful for this medicine.

[Bramma in reply to Ewalt]

Thanks for your reply, does he have tremor if so did it help