Continuous activation of NRF2 can be pro-tumourigenic

[Bolt_Upright]

Hmmm... let's all be careful with our broccoli sprouts!

scienceofparkinsons.com/201...

One final cautionary note before we finish: Despite all the excitement surrounding NRF2, it is important to remember that too much of a good thing can be bad.

Continuous activation of NRF2 can be pro-tumourigenic – that is, it can encourage the growth of cancerous tumours. Cancer cells generate a lot of oxidative stress, which usually helps to kill off the cancer or at least keep the growth under control. Sometimes somatic (or spontaneous) genetic mutations can occur in the NRF2 gene which results in hyperactivity of NRF2 and it continuously activates target genes. These target genes help to reduce the oxidative stress in the cancer cells, which in turns helps to keep those cells alive and multiplying. Thus, one must be careful with over activating NRF2.

[Resano]

For ancient Greeks, the word "pharmakon" meant simultaneously: "remedy", "poison", and... "scapegoat"...

[park_bear]

A good cautionary note. Here is the study with the details:

ncbi.nlm.nih.gov/pmc/articl...

What is needed is a study to assess how much sulfurophane is safe. In the meantime this is a real risk of unknown size. While we are on the subject of carcinogenic supplements, it is very important to be aware of this:

Folate Supplementation Carcinogenic

tinyurl.com/ycdrz5lj

[Bolt_Upright]

I completely missed the fact that the cautionary study was from 2011. I discount anything that is 10 years old

Especially when there are newer studies showing sulforaphane to be anti cancer:

Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells 2021 nature.com/articles/s41598-...

The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review 2018 ncbi.nlm.nih.gov/pmc/articl...

Sulforaphane in broccoli: The green chemoprevention!! Role in cancer prevention and therapy 2020 ncbi.nlm.nih.gov/pmc/articl...

Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells In vitro and In vivo 2019 cancerpreventionresearch.aa...

My broccoli sprout powder arrives tomorrow!

[sharoncrayn in reply to Bolt_Upright]

" I discount anything that is 10 years old "

Very foolish. You would discount probably all the most prescribed PD drugs and at least 20,000 CTs, studies, and articles available on PubMed. Newer is not always better.

sharon

[Bolt_Upright in reply to sharoncrayn]

I'm starting to think you might be more than 10 years old (and you know what that means).