Proteus Mirabalis

[Marcia123]

Anyone have leaky gut and an overgrowth of Proteus mirabilis? I have it in my gut and urine. I also have leaking gut. I found a study showing that Proteus mirabilis could impact motor function. It was done on mice

[Bolt_Upright]

Interesting. Do you have a link to the study you mentioned?

I found this:

Proteus spp. as Putative Gastrointestinal Pathogens 2018: Proteus species are low-abundance commensals of the human gut that harbor significant pathogenic potential; further investigation is needed.

ncbi.nlm.nih.gov/pmc/articl...

Leaky Gut As a Danger Signal for Autoimmune Diseases

Reversing the Leaky Gut as a Potential Therapy

frontiersin.org/articles/10...

Considering the contributions of leaky gut and bacterial translocation to inflammation and multiple diseases, reversing gut leakiness appears to be an attractive therapeutic strategy. Prebiotics and probiotics, for example, can be used to reduce intestinal permeability (139). Diverse probiotic species have been uncovered that possess the properties to protect the intestinal barrier through targeting different components of the mucosal barrier system. The human commensal Bacteroides fragilis may serve as such a probiotic (140). In a mouse model, autism spectrum disorder (ASD) has been shown to be accompanied by intestinal barrier dysfunction, gut microbiota dysbiosis, and leakiness of 4-ethylphenylsulfate (4EPS), which originates from the commensal bacteria. When 4EPS was given to wild-type mice, it directly caused behavioral abnormalities similar to ASD mice. Treatment with B. fragilis reduced the translocation of disease-causative 4EPS, and significantly ameliorated the behavior defects. The therapeutic benefit of B. fragilis is believed to be due to its ability to alter microbial composition and enhance intestinal barrier function (140). B. fragilis is also known for its capability to induce the development of Foxp3+ regulatory T cells, a process regulated by another product of B. fragilis, polysaccharide A (PSA) (141, 142). B. fragilis and PSA are beneficial against inflammatory diseases, such as colitis and experimental autoimmune encephalomyelitis (141, 143). The application of B. fragilis to prevent the leaky gut and reverse autoimmunity warrants further investigation. In a practical point of view, probiotic candidates with different targets on reversing the leaky gut may synergistically act to attenuate disease as thus may serve as a probiotic cocktail. As probiotics are generally considered safe, it is anticipated that they will become cost-effective treatment options for people with autoimmune diseases in the foreseeable future. This is a very young but exciting field in which much still remains to be learned.

[Bolt_Upright in reply to Bolt_Upright]

Don't go looking for Bacteroides fragilis to fix your leaky gut. It seems to be somewhat of a pathogen and does not seem to be for sale. I guess this is where FMT would come in.

[Bolt_Upright]

And this (go to this link then click on the PDF:

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

sciencedirect.com/science/a...

[ncage19]

I had Proteus Mirabilis myself in January 2018 which was found by tests in the hospital and ended up in hospital in intensive care for 11 days, in a coma for 3 of those days, on life support, both lungs collapsed, heart enlarged, both kidneys were taken out by the bug that made a kidney stone that took out the bit where the ureter joins to the right-hand side kidney. It took out the other kidney as well and I was on dialysis. I spent a total of 17 days in the hospital, I even had delirium for 12 days at least where I was a different person. I thought I was a helicopter pilot who drove trucks and came from Wales and was ex-navy. I also thought I had an inbox at the hospital. After spending the 11 days in ICU, I spent 6 days in the general ward and when I got out of hospital I had problems with thrush, and I'm a man. I had septic shock, that's what it gave me and here in Australia where I live, 5000 people die from sepsis in a year and thank God, I wasn't one of them.