I was selected for a clinical trial in Phase 2, for a Mesenchymal Stem Cell Therapy for Parkinson's Disease. Looks promising, any thoughts?

[PrayN4aCure]

uth.edu/news/story.htm?id=3...

[justhavefun2]

Congratulations and a big thank you for participating!! ❤️ I tried to use the link to look at what you’re doing, but it doesn’t work for me.

[Canddy in reply to justhavefun2]

Agree congratulations - sadly I did not qualify for this study - I tried - but had another disqualifying co-condition of inflammatory arthritis.

[laglag]

Briefly, how did you get picked and what qualifications did they require? I read the requirement for ages, but I really didn't see anything else. Will there be placebos?

[Rhyothemis in reply to laglag]

It's placebo controlled.

[PrayN4aCure in reply to laglag]

I contacted Vanessa K. Thyne, MS who is the Clinical Research Coordinator III at the University of Texas, McGovern Medical School in Houston. It was fast and easy for me. At last contact they had 10 or 11 spots open. She is extremely nice and eager to assist anyone who is interested. They expanded the criteria to 2 years rather than 3 that's how I qualified. Yes there will be placebo administered, I believe it was at 33%. At 66% chance, I thought at those odds, I'll do it. She can be reached at 713-500-7127 office. Good Luck!

[Bolt_Upright]

Good luck. It would be cool if you could get a hold of that Marie Bott who participated.

[MarionP]

Seems like it's a really small and very brief study compared to what this piece suggests they are looking for, without knowing anything about their actual methodology, patient selection/exclusion criteria against the general patient population, sufficiently common and paced disease definition, mechanisms of individual disease development criteria and measurement. To me at least. People seem lately very frustrated with earlier slow pace of traditional science procedures, patients for their reasons, treatment developers, investors, and governments for theirs, respectively. Like a certain recently approved Alzheimer's drug we've recently seen.

But if it works, why not I guess, right?

And if over 3-4 years or 10 years to see whether the prodromal symptoms in the revealed "stemmed" cohorts do or don't develop measureable parkinsons, while not developing new kinds of immune effects, cancers, triggers of programmed cell deaths in other systems and the like, we'll just deal with any additional effects as they come...or rather, the accumulated treated patients will. There are always prospective tradeoffs such as what other treatments might you have to forswear and how far down the road to do so, in light on the other hand of the FDA's potential new rush-to-market paradigm. As the saying goes, "You pays your money and you takes your choice.", I can't wait forever."

[Rhyothemis]

Great news. Please post updates.

~

Here's the clinicaltrials.gov database entry which lists details on inclusion criteria, etc.

clinicaltrials.gov/ct2/show...

[Hidden]

I researched that study. I would enthusiastically participate if I had qualified.

[TR8Man]

Have you participated in other clinical trials? What drew you to this study? I'm participating in my second trial...Has to be some good to come from me having this disease.

[PrayN4aCure in reply to TR8Man]

I have not participated in any clinical trials before. I was actually going to travel to Cancun, MX and pay for private treatment but saw this on come up on this forum and decided to look into it. Phase 2 they will be testing what amount of stem cells are the most effective. I believe they’ll be testing at 20 Mil to 50Mil count. 3 infusions August, December, and April. They will monitor the participants for the next 18 months. From the test results from phase 1, Participants should feel some improvement approx 30 days from the 1st infusion. I guess by that time, I’ll know if I am getting the placebo.

[TR8Man in reply to PrayN4aCure]

I have to believe that first 30 days will be tense...just the wait...is this working or not...placebo. I'd like to join the study, but, will have to wait to complete the study I'm in now. -

[LeharLover62]

Congrats, and thank you! We're in the process of moving down to Austin, so we'll consider it also. Though I don't know if he will qualify as he's far enough along to have hallucinations as a side effect of C/L. (BTW, moving with Parkinson's is NOT fun!! I'm a bundle of stress, trying to keep him calm and safe.)

[TR8Man in reply to LeharLover62]

I hope y'all's move to Austin proves to be wonderful....I'm sad about your stress...Keep yourself healthy......PD is NO FUN!! That's for sure..

[LeharLover62 in reply to TR8Man]

Thank you! We hope it's wonderful too.

And yes, I found the study info, looks like hallucinations and a diagnosis more than 10 years ago are exclusions. Treatment gets tougher after 10 years.

clinicaltrials.gov/ct2/show...

[j2jacobs]

Go for it! The results from the Phase I study looked very promising, and importantly, safe. You may want to check that if you wind up in the placebo dosing group and the Phase II is a success that you can receive treatment subsequently in the Phase III study.

[PrayN4aCure in reply to j2jacobs]

That’s the plan.

[Leslim]

When r they planning for phase 3 or is it dependent on phase2 trial?

[kaypeeoh]

I've seen mesenchymal stem cells at work. The clip says they used cells extracted from bone marrow. In my veterinary practice I followed a protocol extracting mesenchyme from fat cells. Apparently for every gram of fat there are thousands more mesenchymal cells than an equal volume of bone marrow. I injected the mesenchyne into a dog with ACL rupture of both stifles (knees). It was a 100# labrador. Generally they are euthanized because nothing can fix the problem in a dog that heavy. But the treatment worked. Two weeks after the injection he could walk and run again.

[Jimmary]

HI PrayN4Cure,

Do you have any updates to share?

Thank you

[jimcaster]

PrayN4aCure Any update?

[PrayN4aCure in reply to jimcaster]

Just gave a detailed update

[jimcaster in reply to PrayN4aCure]

Where?

[seamusw in reply to jimcaster]

yes where

[seamusw in reply to PrayN4aCure]

yes where?

[seamusw]

Sorry to trouble you - but are you able to provide an update? Thanks !