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"We’ve “cured” Parkinson’s in mice hundre... - Cure Parkinson's
"We’ve “cured” Parkinson’s in mice hundreds of times, but no disease-slowing therapy has successfully been translated to humans. Why?
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Farooqji
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Yes, this: " If we want to study aggregation of alpha-synuclein, we wouldn’t use a neurotoxin model which has little to no alpha-synuclein pathology," - MPTP mouse model of parkinsonism.
It's easy to tailor results especially when using mice.
A million dollar question, Farooq! I have asked myself millions of times!!!
Big pharma is still working on the equation of profit!
I have to disagree with you on this big pharma conspiracy theory. While I do think all conspiracy theories are somewhat plausible, look at Biogen coming out with that Alzheimers treatment last week and their stock going to the moon! Trust me, we are close to being next. Huntingtons disease is next, then probaly one more then us. Within the next 3 to 5 years, this is done. Save this post!
Hi Bass,
I will save it! 
I believe there is a post on HU regarding this Alzheimer's "treatment."
Bass, The problem with referring to Biogen's AD drug is that it was accompanied by a credible and compelling news (see Forbes) sources which made the point that the FDA caved to a Big pharmaceutical company, that is, the FDA's own staff said the data wasn't there to justify the decision and in so doing the FDA set back AD research by a decade and by extension perhaps PD research too. (Exactly Despe's point.)
I'm sorry, I don't understand what you mean
Here's the point, Bass, based from the behavioral evidence: Estimated cost based on Biogen's price is $54 Billion to Medicare, $56,000 per year per patient that the patient didn't earn and contribute to pay for, so we do, and the science still doesn't work. Biogen CEO just said to the media: "It's a very fair price." And what actual benefit will be gained?
So are you sure they didn't just buy the committees at FDA for a billion or two per committee in their offshore accounts, along with the corresponding congressional committees and president and friends, lots of money to throw around, and that's just in the U.S. I'd sure take the money if I were on that committee. At that scale, $$50 million per "bribee" is pretty darn cheap.
So the point is that if you pay taxes and co-pays (maybe you do not, so someone else pays for you) then I think if you don't get it by now then it may be a little late for you to benefit from even this watered-down "treatment" either, and why your own pocket is the last place your money should be, so why not steal it, I can put your money to far better use when it is in my own pocket. You don't value it enough to even bother hanging on to it. All I have to do is put my hand in your pocket, maybe say hello to ol' charlie next to it, just to distract you if you can still even tell, and take whatever dough you have for myself.
As the saying goes, it's about the money: "Money always goes where it's treated best (most desired)."
Take the world. If the world cares, then it's up to the world to stop you.
Does that clear it up for you?
Yet none of this supports the assertion that "Big pharma is still working on the equation of profit!" Is the explanation for "no disease-slowing therapy has successfully been translated to humans".
If anything, Biogen's ability to put to market an ineffective drug runs contrary to the suggestion that 'big pharma' cant figure out the profit equation. They obviously can figure the 'equation of profit' if they are doing it with a drug that might not even work.
Maybe, just maybe, the reason for the disparity between successes in mice and humans re PD (or fake PD in mice) is fairly well explained in the article, and lazy big pharma conspiracy rants have nothing to do with it at all.
Im not surprised by bass' confusion. I share it.
The FDA just gave Biogen the green light to make billions without even having to produce a drug that is effective at treating symptoms. You'll not ever get a cleaner example of big pharma in it (& in bed with the FDA) for the money.
I'd like to see a forensic audit of every FDA commissioner over the past ten years. Throw in judges while you're at it.
Yeah it just has nothing to do with the post. Do you think big pharma corruption is the reason that "no disease-slowing therapy has successfully been translated to humans" for PD? I don't.
And again, the Biogen situation is a perfect example of how 'big pharma' is capable of figuring out how to profit. No kidding they are in it for the money.
The estimated total healthcare costs for the treatment of Alzheimer disease in 2020 is estimated at $305 billion, with the cost expected to increase to more than $1 trillion as the population ages. Just consider that whatever percentage of the Alzheimer's population that are candidates for the drug, and the percentage of them the drug is effective for is going to offset the total health care costs by x amount of dollars and improve the quality of life for patients and family members. Hopefully the math works out . To tell the truth, I'm not sure if it does.
This medication doesn't work. I guess that's ok with you.
We induce disease in mice - we don't totally understand what causes PD in people though. It's not the same. If 80% of my symptoms are gone from cutting the PTT tracts in my brain it is not just dopamine or alpha synuclein.
Mice dont get Parkinsons. The researchers induce a condition in the mice that looks like PD. Its not but no one seems to care. When I see the word "mice" in any study report, I stop reading it and go read something else.
Those lucky mice, GymBag.
😍 Couldnt have said it better myself!
Your expression, and you have not "copy righted" it.
In college I had to repeat the studies of a guy who proved LPS (lipopolysaccaride) was the chemical that caused illness and death in mice. He grew E. coli then extracted LPS then injected the LPS into mice. And found it killed the mice. I had to repeat his work. But no matter how many times I grew E. coli and injected LPS into mice I couldn't even make them sick. The instructor decided I wasn't following the protocol so I got a poor grade and ultimately didn't graduate cum laude for that reason. Years later in vet med school I found the lipid fraction was the agent of illness but the extraction process had included dissolving the lipid so it wasn't LPS it was PS that I had been injecting. So this guy had completely falsified his results and gotten a PhD on that basis.
The point is the 'publish or perish' mentality rules higher education.
it wasn't LPS it was PS??? Thats BS! sorry to hear you got hosed.
It didn't keep me from being accepted into vet med school so no big deal.
Einstein didn't do well in school. So really it's a good thing he never took up physics. Instead he was assigned to the postal service opening up packages suspected to be bombs. He just stumbled into his theories of relativity on weekends.
because when they give PD to mice, they know exactly what the damage is becaus emice dont naturally get PD, they have to have caused it artificially. When people get it, its not so easy to know why the disease has occurred, there could be dozens of causations. Plus, mice are lucky! This, I know.
"Plus, mice are lucky! This, I know."
Right. I spent a couple years in Gordon Harrington's famous mouse lab in the 1970s. Care to guess what I saw?
Mice are lucky, this I know, 'cause the Bible tells me so
The isle of dr moreau for mice?
Something like that.
Good one Faroogi. It reinforces what I've always said & say. If an article uses the words "cured" or "discovery" or "breakthrough" -- run the other way. Actually, articles are usually so bad, we should pay little attention to them.
No, you should pay attention to them, you are the one paying for it.
Profit before humanity!!!
