Terazosin ? I have researched using P... - Cure Parkinson's

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Terazosin ? I have researched using Parkinson's Online - 19 items so far . . .

FMundo profile image
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2019 Jan “Expert Briefings” of Non-motor Symptoms: What’s New ? – Dr. Ronald Pfeiffer

Obstructive Symptoms: Treatment Alpha-1 adrenergic antagonists – Terazosin

2019 April Monthly Research Review, Science of Parkinson’s Disease (SoPD)

2019 May The Futile Hunt for Disease Modifying Therapies | Journal of Parkinson's Disease– by Ben Stecher

“…Also very recent reports of the benefits of terazosin and related compounds (Alpha-1-adrenergic blocking agents), used for the urinary symptoms of prostate disease and/or for hypertension - slows or prevents neuro-degeneration. A prospective study [TZ-PD Ph II 13 ppl trial for safety & tolerability - NCT03905811 ] confirmed benefits in a small number of patients. But the important research came from the Parkinson's Progression Markers Initiative database [ PPMI ], showing that this class of drug reduced hospital or clinic visits, disease complications, as well as specific scores for walking/gait/coordination measures, for and neuropsychiatric scores. The diagnosis of new Parkinson's disease was reduced by 38%.”

2019 Sept Science Daily – Big Data, bench science suggests dug may slow Parkinson’s progression in people . . .

sciencedaily.com/releases/2....

2019 Sept Parkinson’s News Today (PNT) Blood Pressure and Prostate Treatment May Prevent or Slow Parkinson’s . . .

2019 Sept Monthly Research Review – September, (SoPD)

“Chinese and US researchers published data suggesting that prostatic hyperplasia and hypertension drug, terazosin could be repurposed for Parkinson’s. Multiple PD models & human medical database evidence were presented in their report. They found that Terazosin activates phosphoglycerate kinase 1 (PGK1), one of the first enzymes in ATP production (the energy that cells run on). Treatment with terazosin rescued multiple neurotoxin & genetic models of Parkinson’s, and human dopamine neurons from LRRK2-G2019S patients that were grown in cell culture. MarketScan medical records database analysis found 2880 Parkinson’s patients with PD taking Terazosin (or similar) “had fewer PD-related diagnoses” than 15,409 individuals with PD + no Terazosin. PD-free individuals on Terazosin had reduced frequency of PD (0.62; P < 0.0001). A Phase II clinical trial for Terazosin in Parkinson’s is already being organised. It is a double blind, placebo controlled,12 weeks treatment in 20 people with PD (1:1 randomisation). Safety is the primary outcome, and it will be reporting in early 2020 (Click here to read the report, click here to read more about the clinical trial, click here to read the press release, click here for a good overview of this research, and click here to read an SoPD post on this topic).”

2019 Sept Prostate drug may slow Parkinson’s disease – BBC Online

bbc.com/news/health-49713407

2019 Sept 18th Repurposing from enlarged prostates to Parkinson’s (SoPD)

What is terazosin, what a receptor antagonist is, what the alpha-adrenergic receptor functions are, mitochondria, etc. etc.

2019 Sept Targeting neurons in the gastrointestinal track to treat Parkinson’s Disease – HealthUnlocked (HU)

(Drug mentioned of consequence in clinical trial AE)

2019 Oct The 2019 Linked Clinical Trials meeting (SoPD)

"There is a great deal of Parkinson’s preclinical research that is focused on clinically available drugs (for a good example see the recent SoPD post on the prostate drug Terazosin – click here to read that post). We don’t need to re-invent the wheel and come up with new formulations of old drugs to test whether a theory might work. That process requires years of research and longer clinical safety testing. We can use a clinically available drug, which will give us a proof of concept as to whether the hypothesized biology is important/relevant to Parkinson’s."

2019 Dec 2019 Year in Review (SoPD)

"In addition, there were a host of new clinical trial initiated, many of which are exploring entirely new experimental therapies. These include . . .

Terazosin – This prostatic hyperplasia and hypertension drug was found to enhance Phosphoglycerate kinase 1 (Pgk1) activation & a phase II trial was immediately initiated (Click here to read a SoPD post on this topic)."

2020 Jan The Road Ahead (SoPD)

"Another mitochondrial-focused clinical trial initiated in 2019 was a drug-repurposing study involving the prostatic hyperplasia and hypertension drug, Terazosin. Researchers published data suggesting that terazosin could rescue models of Parkinson’s by boosting energy production in mitochondria. A 12 week Phase II clinical trial for Terazosin in Parkinson’s was set up to assess safety of the drug in peope with Parkinson’s, and it is scheduled to finish in 2020 (Click here to read about the clinical trial and click here to read an SoPD post on this topic)."

2020 May Monthly Research Review – May 2020 (SoPD)

"New clinical study registered: Researchers will be exploring the effect of an adrenergic receptor blocker (Terazosin) on cardiac & striatal transporter uptake in pre-motor & symptomatic Parkinson’s (Click here to read more about this)."

2102 Feb Alpha Blockers for Enlarged Prostate May Lower Parkinson’s Risk (PNT)

2102 Feb Association of Glycolysis-Enhancing (alpha)-1 Blockers With Risk of Developing Parkinson’s Disease (JAMA)

jamanetwork.com/journals/ja...

2102 Feb Could a Prostate drug slow or stop Parkinson’s? by Clare Bale, Parkinson’s UK

2102 Feb Could prostate drugs reduce Parkinson’s disease risk? Medical News Today

2102 Feb Lower Risk of Parkinson’s Disease associated with Prostate Medication Hindustan Times

2102 Terazosin for Parkinson’s Disease (TZ-PD) – ClinicalTrials.gov

Considering the print type that Simon Stott is allocating to this drug, I'm inclined to think it worth watching going forward.

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11 Replies
JerryinSATX profile image
JerryinSATX

I started taking Terazosin a few months ago and I believe it has positively impacted my PD symptoms. I am having fewer off-time moments and sleeping better. I’ll talk to my Neurologist about maybe reducing my Senimet dosage.

Thal profile image
Thal

Was on Avodart for a while before I had my TURP. Found out it also enhances dopamine but side effects are depression, diabetes, erectile dis, cognition, cholesterol,etc. ...

Despe profile image
Despe in reply to Thal

"Avodart" "TURP"

Is the first one a medication similar to Terazosin? What does the second stand for?

Thank you!

Thal profile image
Thal in reply to Despe

Transurethral resection of the prostate

Despe profile image
Despe in reply to Thal

Did it work? Was it for frequent urination? My husband would be interested if the results are satisfactory. Thanks!

Thal profile image
Thal in reply to Despe

it has satisfactorily worked for frequent urination. was over a decade ago. had a good urologist which i wish for him for medical advice.

Despe profile image
Despe in reply to Thal

Thank you! His urologist's wife has PD and is very understanding. I will make an appointment to ask him about the procedure.

pwpwifekim profile image
pwpwifekim

We asked my HWP’s doctor about this about 18 months ago when an article on it appeared. They were about to start clinical trials on Terazosin and Parkinson’s in Europe. HWP was taking blood pressure meds and we proposed swapping them for Terasosin. Doctor saw no harm and there were no negative changes. His UPDRS scores are somewhat better and his Parkinson’s meds have not changed. The neuroprotective benefits (if any) won’t be evident for a bit longer, but he’s in a very good place for now. Unless there is a risk of hypotension issues with Terazosin, it is worth checking with your doctor.

sharoncrayn profile image
sharoncrayn

Ter.... and its drug class has been around for probably 30 years as a BP and BPH med. CT for PD is tiny (n=13). Another China and U of Iowa database manipulation.

FMundo profile image
FMundo in reply to sharoncrayn

Then perhaps Simon Stott should "cool his jets." ?

sharoncrayn profile image
sharoncrayn in reply to FMundo

round and round we go

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