More conclusive proof that chemical contaminants cause Parkinson's

[pdpatient]

The following NY Times article discusses the information contained in a recent book about "Ending Parkinson's"

nytimes.com/2020/07/20/well...

[park_bear]

Ending Parkinson's Disease: The Book YouTube channel:

youtube.com/channel/UCtFqUF...

At Amazon:

amazon.com/Ending-Parkinson...

My writing on the subject – beware permethrin, a common household insecticide:

Parkinson's and Pesticides

tinyurl.com/y8tckmx4

[Rhyothemis in reply to park_bear]

I wonder what the OR is for rotenone in pasta sauce ...

[Rhyothemis]

I saw a good talk by Beate Ritz at the virtual MSA conference about a couple of weeks ago. Here's a paper by her:

Of Pesticides and Men: a California Story of Genes and Environment in Parkinson's Disease

pubmed.ncbi.nlm.nih.gov/268...

So now I have been reading up on PON1 and the other paraoxonases; it's quite fascinating.

There are shared mechanisms with development of autism.

Seems like brightly colored wall paint should be on the PD 'avoid' list:

youtu.be/Av5o-QVSWHA?t=3792(Not working as expected?)

[park_bear in reply to Rhyothemis]

nature.com/articles/npjpark...

"exposure to a commonly used class of insecticide, pyrethroids, synergized with the risk conferred by this SNP (odds ratio=2.48, P=0.007), thereby identifying a novel gene–environment interaction that promotes risk for PD via alterations in immune responses"

[GinnyBerry]

Well, as a scientist, I wouldn’t call this “conclusive proof”. 😀

But, I certainly find it compelling. I am very healthy. I have not been exposed to pesticides or the like. But I first started seeing my symptoms— loss of taste and smell — at 42. And I’m a chemist. A chemist who stupidly took pride in being able to identify chemicals by their smell.

The unique chemicals I was most exposed to were isocyanates, carbodiimides, and, to a lesser extent, cyanides. Like most chemists, I liberally used isopropanol, toluene, pyridine and other organic solvents.

[pdpatient in reply to GinnyBerry]

GinnyBerry, you are correct. I should have used the word "compelling proof" and not "convincing".

People ask me what difference does it make what causes or caused Parkinson's in me or anyone else. The answer is that the knowledge at least gives us a fighting chance to save or at least prolong the life of the remaining dopamine producing neurons in us. In turn, this would hopefully give us a little more time on the planet with a somewhat better quality of life.

BTW, you seem to have handled your diagnosis pretty well at 42. I was diagnosed at 48 (the same summer as Robin Williams) and had a pretty bad time with it. Suffice it to say that I am a huge fan of his movies and nearly followed him to the next world or wherever he ended up 😇