My "PD" is modulated by three factors. Dysautonomia is one.

[aspergerian]

My "PD" is modulated by:

Norepinehrine loss in CNS. Amantadine helps.

Dysautonomia (ANS pathologies). Eg, elevated norepinephrine in periphery.

Midface hypoplasia (eg, severe malocclusion, high arched palate). Also, I've come to believe: distorted development of my insular cortices and interconnected neural tissues.

For related discussion, see:

Dysautonomia subgroup in PD - HU PD.

healthunlocked.com/parkinso...

[rescuema]

Serotonin (affected by levodopa) is a chemical precursor to melatonin and helps maintaining sleep while dopamine is a precursor to norepinephrine which is involved in producing and releasing melatonin in the pineal gland. Thus a double whammy combined NT deficits with l-dopa induced altered DNA methylation and PD progression could lead to sundowning syndrome, where melatonin replacement and consistent outdoor physical exercise could be helpful.

List of serotonin deficiency symptoms -

medicalnewstoday.com/articl...