How common is depression in PD?

[kaypeeoh]

Just today this came to my mailbox:

Background:

Fatigue is the most common symptom of MS and has no effective pharmacotherapy.

Since both are brain diseases, PD and MS have similar signs. I was first diagnosed with PD because an MRI showed white spots in the brain. Similar to the alpha psi-nuclein seen in PD?

Has anyone tried ketamine as a treatment for depression?

Being a veterinarian, I had a dozen bottles of ketamine on the shelf. A year ago I had a bout of depression after the diagnosis of PD on top of the MS. I found videos of ketamine clinics giving 0.5mg/kg IV as a treatment for depression unresponsive to standard treatments. At work I'd accidentally given a 10X overdose of ketamine to a patient and she survived.

Depression makes it easier to try dangerous things. So I put in a catheter and started an IV drip of ketamine. I was home alone, my wife was in Connecticut visiting our daughter. The videos showed people on a ketamine drip laughing maniacally. Before starting the drip I started the timer on my watch: Sunday morning 10AM.

They talk about 'out of body' experiences on ketamine. For me that was an understatement. I sat in my favorite chair as the drip started. The opposite wall was bookshelves. Shortly the wall bent 45 degrees and I wondered why the books weren't falling out. Then I was hovering in the air above the room, then I was outside the room, then I was outside the planet in a rocket ship with the earth visible below and to my left while the moon was above and to my right. Then I was back in my chair but my hands had turned to stone.. Then they'd turned to metal. Then they weren't metal but I was wearing aluminum gloves. It felt like hours had gone by. I wondered why the sun wasn't setting. I wondered if I'd damaged my brain. What if I was trapped in this nightmare world unable to function. The movie, Awakenings, came to mind. Would someone from work come to find out why I hadn't gone to work that morning?

Hours later my frozen hands regained function. Then hours later I was able to stand and while holding the wall made my way into the kitchen and splash cold water in my face. Then hours later I was able to walk back to the chair. Then I remembered my watch. I was still wondering why the sun was still out. Had I gone 24 hours in this state? I looked at the watch; Sunday morning, 10:10. Yikes, what had felt like hours or days had actually lasted 10 minutes.

So no interest in doing it again. The ketamine causing me loss of control over my mind and body has stayed with me. My ketamine experience was a lot more involved but this post is long enough. Kinda like acid, anyone wanting to try it should have someone to help talk them through the hallucinations.

kpo

[parkie13]

5 to 10mg lithium orotate stopped my crying. I was not happy but I did not think I had depression. That is a small dose.

[rescuema]

Vitamin D deficiency is a high culprit for the winter blues and depression. While being cooped up and hardly active with outdoor activities, be sure you're not deficient (check your serum level) and supplement D3 along with K2.