Skim melk: Milk Fat Intake and Telomere Length in U.S. Women and Men: The Role of the Milk Fat Fraction.
2019.
Open access.
Skim melk: Milk Fat Intake and Telomere L... - Cure Parkinson's
Skim melk: Milk Fat Intake and Telomere Length in U.S. Women and Men: The Role of the Milk Fat Fraction.
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aspergerian
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Association does not equal causation! From the study text:
"Causation is a possibility, and the present findings warrant additional research in this area, but the scope of this study does not allow causal conclusions"
In particular, consumption of high milk fat products is generally regarded as unhealthy. People who are prone to doing this can be expected to engage in other dietary habits that are also regarded as unhealthy.
I explored this issue more deeply with regard to egg consumption here:
A Tale Of Two Studies Leads To A Deeper Understanding Of Cardiovascular Disease
Do eggs make cardiovascular disease better or worse? What is the root cause of cardiovascular disease anyway?
I did some searching into dairy products as a result of Dr Mischleys survey of PD patients and the things most attributed to faster progression, dairy was one of those at the top of the list. I mostly just browsed some articles associating PD and dairy, I was surprised to find quite a few, so not surprised to find more info on ill effects of dairy.I
I do want to mention cardiovascular as I set out several years ago to find the best route to avoiding heart disease. Cholesterol is associated but not causal in this case, especially since it is known to protect our cells, especially in the brain. I have found through numerous sites like Dr Perlmutter, Dr William Davis, Dr Axe, Dr Jockers, Dr Davis Kharrazin, Dr Tim Noakes that a high carbohydrate diet and high sugar is the culprit behind our veins getting damaged with cholesterol trying to come to the rescue to protect the damage to the veins. I am not versed in the technical aspects of all of it but have enough grasp to feel like I can now feel like I am on the right track.
Very interesting the information on AGEs and CML, I'm inclined to think this may link to why they say do not Bbq meats and end up with charring.
Indeed, high sugar consumption is the other cardiovascular disease culprit:
Sugar, Fat And Cardiovascular Disease
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I applaud Laurie Mischley for her dedication and ongoing good work in Parkinson's. That said, the results of her survey work are also associations. You will not do yourself any harm by minimizing butterfat. I personally do try to take it easy on the dairy. However, in my opinion the jury is still out regarding causation.
If the dairy-PD relationship is causal, I would be suspicious of d-galactose; it is used to induce neurodegeneration in lab animals at high doses.
I would like to see studies on dietary intake of oxidized cholesterol vs non-oxidized cholesterol on health in general. Apparently high temperature cooking (frying, roasting), drying (as in dried eggs), freezing and storing, and microwave cooking all increase oxidation of cholesterol in food. I've stopped microwaving my daughter's favorite frozen mac and cheese; I now allow it to thaw a bit to remove from the packaging and put it in a pot on the stove with a little extra milk (this is a once a week treat). I should probably try to make it from scratch, but that is my one night off cooking...
microRNAs are also found in milk; not much is known except that they are in there and they are orally available. {goes and checks literature for recent findings ... }
Well, here's a review I need to read:
onlinelibrary.wiley.com/doi...
I've recently been studying about AGEs, Advanced Glycation End products in relation to your comment about dry heat cooking increasing AGEs in meats, proteins. It also happens in our body when we combo protein sugar and fats in a meal. AGEs are known to cause inflammation.
I avoid dietary AGEs whenever possible, but it seems to me at this point that endogenous AGEs are more problematic. We see a lot of the damage they can do in uncontrolled diabetes, for example. Vegetarians and vegans also have problems with AGEs, most likely due to not consuming taurine or carnosine. Taurine, carnosine and thiamine supplements seem to be helpful in controlling endogenous AGEs. Some people take beta-alanine which is a carnosine pre-cursor and is cheaper than carnosine; I have not tried it.
But I so love a dish of ice cream after dinner. It must go, too. Boo-hoo.
Banana ice cream is pretty good (frozen ripe banana slices in a food processor, pulse until ice cream consistency).
Interesting subject, however the study says: "Information about the thermal processing of milk was not collected by the NHANES questionnaire. Specifically, no data were gathered about milk pasteurization versus ultra-heat-treated (UHT) milk." Since ultra-pasteurized milk's protein is damaged by high heat it's hard to make sensible conclusion about results.
Holy ....!
en.wikipedia.org/wiki/Ultra...
"Ultra-high temperature processing (UHT), ultra-heat treatment, or ultra-pasteurization[1] is a food processing technology that sterilizes liquid food by heating it above 135 °C (275 °F) – the temperature required to kill bacterial endospores – for 2 to 5 seconds.[2] UHT is most commonly used in milk production, but the process is also used for fruit juices, cream, soy milk, yogurt, wine, soups, honey, and stews.[3] UHT milk was first developed in the 1960s and became generally available for consumption in the 1970s.[4]
The heat used during the UHT process can cause Maillard browning and change the taste and smell of dairy products.[5] .... A significant percentage of milk sold in the US as organic food is UHT treated.[6] "
These temperatures result in the creation of artery damaging advanced glycation end products. Mallard browning is evidence that this is occurring. For details see my writing here: tinyurl.com/y6agl45j
These toxic chemicals are better absorbed in the presence of high concentrations of fat such as found in whole milk.
Excellent elucidation! Thank you.
and oxidized cholesterol, especially if stored for long periods:
A few years ago I used to make my own kefir and at some point realized that ultra-pasteurized milk is impossible to ferment which prompted me to look into the milk processing details and lead to discovery of AGE products, however I don't remember ever hearing of Maillard browning - there is always something new to learn!
Thank you for the link to your article - a lot of in depth information which is good to be aware of.
Another stepping stone to trying to conquer inflammation, change how I cook on top of what I eat.
I have some pretty extreme problems with inflammation and I have to say,
it gets a bit daunting at times. Another way to lower systemic inflammation is to maintain skin barrier
function - a good lotion like CeraVe is very helpful. I now have eczema
so I am learning more than I ever wanted about the topic. Robathol Bath
Oil, bleach baths (shockingly enough - bathing in dilute bleach solution
is actually good for the skin), etc. And we recently bought some home
air filter units since particulate matter is bad and also I have a dust
mite allergy.
Yes, and another source of system inflammation is the poor quality of oil we ingest. Get to know what has omega 6 oil and which foods are rich in omega 3. Modern humans eat far too much omega 6 and not enough 3. The ratio should be no higher than 4 to 1 (omega 6 to 3). Also, don't eat anything that smells even slightly rancid and try not to burn oil which oxidizes it and ruins it. Cold pressed olive oil is ok. Adding ground flax or chia seeds to your oatmeal (porridge) is a good way to increase omega 3. There's always more we can do, but I've seen it pay off for me.
Good points, just want to add that ground flax goes rancid very fast. It's good to grind it yourself before each use or if this is inconvenient then you can store a batch of fresh ground flaxseed in freezer to prevent rancidity.
Right. About once a week, I grind it in a coffee grinder and put it in the fridge in a sealed container. It tastes a little buttery and nutty. I also throw an ounce or two of crushed walnuts in my oatmeal. Some fruit (ground dates and apple sauce are good) but no refined sugar or salt. I'm loving it right now! My dx was almost 12 years ago, and I'm still doing pretty well. Of course diet is just one thing to work on, but it's an important thing.
Thanks for sharing about dates and walnuts. Doing well after 12 years dx sounds very encouraging! Would you mind to share what else do you do to keep yourself in good shape?
Sure, glad to. Here's a link to a conversation about what I do for exercise: healthunlocked.com/parkinso...
More (some would say long-winded and opinionated) thoughts about Bacillus subtilis: healthunlocked.com/parkinso...
Here's a link to 3nB (celery seed extract) that I take (although it doesn't work for everyone, it seems to help me): healthunlocked.com/parkinso...
I also take a few more supplements:
D3 (if I can't get outside in the sun for 1/2 hour/day
K2 (MK-7)
B12
Lutein
Omega 3 DHA from algae to avoid heavy metals and other junk
Fisetin and Alma powder (very good antioxidants)
Turmeric and Ginger
B1 seems to take the edge off of my "down" times.
Finally, I've cut waaay down on animal based food and protein. We need less protein than most believe and it's available from plants, IMO.
Thank you, JerMan for such detailed response and the links. I also take most of the supplements you've mentioned except for lutein and fisetin - will have to look into their benefits for PD, but have to admit I hate taking pills and feel that I take enough of them already...
II've tried various sources of omega-3s (fish, mussels, algae oil supps, fish oil supps, flax, chia) - the only one I've noticed any difference from is salmon roe (the omega-3s are mostly in phospholipid form, also has furan fatty acids which might be good or bad). I'm a reproductive age female so I should be able to convert ALA to DHA (men convert very little), but like I said, flax and chia did nothing. Well, flax did help with fibrocystic breast - probably the lignans. Chia is high in oxalates, so not good for me with NLRP3 inflammasome problems (Familial Mediterranean Fever gene). Pity because I really liked buckwheat chia bread (buckwheat is also very high in oxalates). Interestingly enough I've heard/read researchers argue that the nitro-lipids in fish oil (yup, partially rancid) are the beneficial constituents:
All neurodegenerative disorders involve inflammatory processes. I didn't read the article, but I know that dairy is inflammatory. Many adults become lactose intolerant.
Milk, organic or not, comes from lactating animals. Elevated hormones induce lactation and are naturally present in milk, none of us need these hormones in our bodies, in addition to the ubiquitous presence of pesticides and antibiotics.
There are many other better sources of calcium. I personally will eat grassfed ghee, but no other dairy products.
SE
Dairy is problematic. It is worse if it is harvested from A1 milk rather than A2. Lactose intolerance isn't the only problem. No adult should be drinking milk.
I have found studies linking dairy to problems in the gut effecting PD.
Absolutely no dairy for me for the last 4 years. I missed cheese for a month or so, but no more. If you "need" milk, cheese, or butter you're lucky to be living at a time when vegan alternatives are available and delicious.
Just this morning my family was begging me to allow dairy again. They miss milk with the cereal and cream in the coffee. It's not gonna happen on my watch.
I combine 1/2 almond milk and 1/2 coconut milk, then add coconut cream for richness. It is a good substitute for fluid dairy.
Found this video that explains why we're addicted to dairy, and cheese especially.
I wonder if the dairy is from cows fed gm grain or if grass fed is included too. In NZ our cows wander free eating grass although may get a silage or grain or brassica top up in winter. I assume grass fed cows produce a healthier milk and butter?
I would think that they'd generally have fewer antibiotics in them and in their milk etc. But milk comes from cows that are (or recently were) pregnant, so all the hormonal problems are still there. Cheese concentrates it all. Still, grass fed, open range would be somewhat better I'd guess.
All these articles by park bear (a.k.a. Wilderness Voice) are deep dives in molecular biology and each is important to us PWPs.
Added to your lifestyle changes of alternative and complementary therapies for PD should be to read all the links park bear post.
Thank you, PB.
Indeed! Very important essays by par_bear.
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